Three-peptide control of pulsatile and entropic feedback-sensitive modes of growth hormone secretion: Modulation by estrogen and aromatizable androgen

Johannes D. Veldhuis, Cyril Y. Bowers

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

The present review highlights a simplified perspective of growth hormone (GH) secretory control, which incorporates the individual and joint effects of final-common signals that converge on somatotrope cells. Critical peptidyl effectors are GH-releasing hormone (GHRH), GH-releasing peptide (GHRP, ghrelin), and somatostatin. The latter three-peptide ensemble mediates stimulation, inhibition, and feedback suppression of GH secretion via homologous and heterologous interactions. Pubertal sex steroids putatively act via post-aromatized estrogen (e.g., testosterone converted to estradiol by aromatase) to augment sensitivity to GHRH, potentiate GHRP action, and mute somatostatin restraint. The dynamic interactions in this three-peptide network, rather than the activity of any single effector, subserve core adaptations in GH secretion across development.

Original languageEnglish (US)
Pages (from-to)587-605
Number of pages19
JournalJournal of Pediatric Endocrinology and Metabolism
Volume16
Issue numberSUPPL. 3
StatePublished - 2003

Keywords

  • Adolescence
  • Androgen
  • Estrogen
  • IGF-I
  • Pituitary
  • Puberty
  • Secretion feedback
  • Sex steroids
  • Somatotrope
  • Testosterone

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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