Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: Clinical correlations and comparison to Lund-Mackay scoring

John F. Pallanch; Lifeng Yu; David Delone; Rich Robb; David R. Holmes; Jon Camp; Phil Edwards; Cynthia H. Mccollough; Jens Ponikau; Amy C. Dearking; John Lane; Andrew Primak; Aaron Shinkle; John Hagan; Evangelo Frigas; Joseph J. Ocel; Nicole Tombers; Rizwan Siwani; Nicholas M. Orme; Kurtis B. Reed; Nivedita Jerath; Robinder Dhillon; Hirohito Kita

doi:10.1002/alr.21219

Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: Clinical correlations and comparison to Lund-Mackay scoring

John F. Pallanch, Lifeng Yu, David Delone, Rich Robb, David R. Holmes, Jon Camp, Phil Edwards, Cynthia H. Mccollough, Jens Ponikau, Amy C. Dearking, John Lane, Andrew Primak, Aaron Shinkle, John Hagan, Evangelo Frigas, Joseph J. Ocel, Nicole Tombers, Rizwan Siwani, Nicholas M. Orme, Kurtis B. ReedNivedita Jerath, Robinder Dhillon, Hirohito Kita

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Background: We aimed to test the hypothesis that three-dimensional (3D) volume-based scoring of computed tomography (CT) images of the paranasal sinuses was superior to Lund-Mackay CT scoring of disease severity in chronic rhinosinusitis (CRS). We determined correlation between changes in CT scores (using each scoring system) with changes in other measures of disease severity (symptoms, endoscopic scoring, and quality of life) in patients with CRS treated with triamcinolone. Methods: The study group comprised 48 adult subjects with CRS. Baseline symptoms and quality of life were assessed. Endoscopy and CT scans were performed. Patients received a single systemic dose of intramuscular triamcinolone and were reevaluated 1 month later. Strengths of the correlations between changes in CT scores and changes in CRS signs and symptoms and quality of life were determined. Results: We observed some variability in degree of improvement for the different symptom, endoscopic, and quality-of-life parameters after treatment. Improvement of parameters was significantly correlated with improvement in CT disease score using both CT scoring methods. However, volumetric CT scoring had greater correlation with these parameters than Lund-Mackay scoring. Conclusion: Volumetric scoring exhibited higher degree of correlation than Lund-Mackay scoring when comparing improvement in CT score with improvement in score for symptoms, endoscopic exam, and quality of life in this group of patients who received beneficial medical treatment for CRS.

Original language	English (US)
Pages (from-to)	963-972
Number of pages	10
Journal	International Forum of Allergy and Rhinology
Volume	3
Issue number	12
DOIs	https://doi.org/10.1002/alr.21219
State	Published - Dec 2013

Keywords

Computed tomography
Computer-assisted image analysis
Endoscopy
Lund-Mackay
Quality of life

ASJC Scopus subject areas

Immunology and Allergy
Otorhinolaryngology

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10.1002/alr.21219

Cite this

Pallanch, J. F., Yu, L., Delone, D., Robb, R., Holmes, D. R., Camp, J., Edwards, P., Mccollough, C. H., Ponikau, J., Dearking, A. C., Lane, J., Primak, A., Shinkle, A., Hagan, J., Frigas, E., Ocel, J. J., Tombers, N., Siwani, R., Orme, N. M., ... Kita, H. (2013). Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: Clinical correlations and comparison to Lund-Mackay scoring. International Forum of Allergy and Rhinology, 3(12), 963-972. https://doi.org/10.1002/alr.21219

Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: Clinical correlations and comparison to Lund-Mackay scoring. / Pallanch, John F.; Yu, Lifeng; Delone, David et al.
In: International Forum of Allergy and Rhinology, Vol. 3, No. 12, 12.2013, p. 963-972.

Research output: Contribution to journal › Article › peer-review

Pallanch, JF, Yu, L, Delone, D, Robb, R, Holmes, DR, Camp, J, Edwards, P, Mccollough, CH, Ponikau, J, Dearking, AC, Lane, J, Primak, A, Shinkle, A, Hagan, J, Frigas, E, Ocel, JJ, Tombers, N, Siwani, R, Orme, NM, Reed, KB, Jerath, N, Dhillon, R & Kita, H 2013, 'Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: Clinical correlations and comparison to Lund-Mackay scoring', International Forum of Allergy and Rhinology, vol. 3, no. 12, pp. 963-972. https://doi.org/10.1002/alr.21219

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title = "Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: Clinical correlations and comparison to Lund-Mackay scoring",

abstract = "Background: We aimed to test the hypothesis that three-dimensional (3D) volume-based scoring of computed tomography (CT) images of the paranasal sinuses was superior to Lund-Mackay CT scoring of disease severity in chronic rhinosinusitis (CRS). We determined correlation between changes in CT scores (using each scoring system) with changes in other measures of disease severity (symptoms, endoscopic scoring, and quality of life) in patients with CRS treated with triamcinolone. Methods: The study group comprised 48 adult subjects with CRS. Baseline symptoms and quality of life were assessed. Endoscopy and CT scans were performed. Patients received a single systemic dose of intramuscular triamcinolone and were reevaluated 1 month later. Strengths of the correlations between changes in CT scores and changes in CRS signs and symptoms and quality of life were determined. Results: We observed some variability in degree of improvement for the different symptom, endoscopic, and quality-of-life parameters after treatment. Improvement of parameters was significantly correlated with improvement in CT disease score using both CT scoring methods. However, volumetric CT scoring had greater correlation with these parameters than Lund-Mackay scoring. Conclusion: Volumetric scoring exhibited higher degree of correlation than Lund-Mackay scoring when comparing improvement in CT score with improvement in score for symptoms, endoscopic exam, and quality of life in this group of patients who received beneficial medical treatment for CRS.",

keywords = "Computed tomography, Computer-assisted image analysis, Endoscopy, Lund-Mackay, Quality of life",

author = "Pallanch, {John F.} and Lifeng Yu and David Delone and Rich Robb and Holmes, {David R.} and Jon Camp and Phil Edwards and Mccollough, {Cynthia H.} and Jens Ponikau and Dearking, {Amy C.} and John Lane and Andrew Primak and Aaron Shinkle and John Hagan and Evangelo Frigas and Ocel, {Joseph J.} and Nicole Tombers and Rizwan Siwani and Orme, {Nicholas M.} and Reed, {Kurtis B.} and Nivedita Jerath and Robinder Dhillon and Hirohito Kita",

year = "2013",

month = dec,

doi = "10.1002/alr.21219",

language = "English (US)",

volume = "3",

pages = "963--972",

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T1 - Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis

T2 - Clinical correlations and comparison to Lund-Mackay scoring

AU - Pallanch, John F.

AU - Yu, Lifeng

AU - Delone, David

AU - Robb, Rich

AU - Holmes, David R.

AU - Camp, Jon

AU - Edwards, Phil

AU - Mccollough, Cynthia H.

AU - Ponikau, Jens

AU - Dearking, Amy C.

AU - Lane, John

AU - Primak, Andrew

AU - Shinkle, Aaron

AU - Hagan, John

AU - Frigas, Evangelo

AU - Ocel, Joseph J.

AU - Tombers, Nicole

AU - Siwani, Rizwan

AU - Orme, Nicholas M.

AU - Reed, Kurtis B.

AU - Jerath, Nivedita

AU - Dhillon, Robinder

AU - Kita, Hirohito

PY - 2013/12

Y1 - 2013/12

N2 - Background: We aimed to test the hypothesis that three-dimensional (3D) volume-based scoring of computed tomography (CT) images of the paranasal sinuses was superior to Lund-Mackay CT scoring of disease severity in chronic rhinosinusitis (CRS). We determined correlation between changes in CT scores (using each scoring system) with changes in other measures of disease severity (symptoms, endoscopic scoring, and quality of life) in patients with CRS treated with triamcinolone. Methods: The study group comprised 48 adult subjects with CRS. Baseline symptoms and quality of life were assessed. Endoscopy and CT scans were performed. Patients received a single systemic dose of intramuscular triamcinolone and were reevaluated 1 month later. Strengths of the correlations between changes in CT scores and changes in CRS signs and symptoms and quality of life were determined. Results: We observed some variability in degree of improvement for the different symptom, endoscopic, and quality-of-life parameters after treatment. Improvement of parameters was significantly correlated with improvement in CT disease score using both CT scoring methods. However, volumetric CT scoring had greater correlation with these parameters than Lund-Mackay scoring. Conclusion: Volumetric scoring exhibited higher degree of correlation than Lund-Mackay scoring when comparing improvement in CT score with improvement in score for symptoms, endoscopic exam, and quality of life in this group of patients who received beneficial medical treatment for CRS.

AB - Background: We aimed to test the hypothesis that three-dimensional (3D) volume-based scoring of computed tomography (CT) images of the paranasal sinuses was superior to Lund-Mackay CT scoring of disease severity in chronic rhinosinusitis (CRS). We determined correlation between changes in CT scores (using each scoring system) with changes in other measures of disease severity (symptoms, endoscopic scoring, and quality of life) in patients with CRS treated with triamcinolone. Methods: The study group comprised 48 adult subjects with CRS. Baseline symptoms and quality of life were assessed. Endoscopy and CT scans were performed. Patients received a single systemic dose of intramuscular triamcinolone and were reevaluated 1 month later. Strengths of the correlations between changes in CT scores and changes in CRS signs and symptoms and quality of life were determined. Results: We observed some variability in degree of improvement for the different symptom, endoscopic, and quality-of-life parameters after treatment. Improvement of parameters was significantly correlated with improvement in CT disease score using both CT scoring methods. However, volumetric CT scoring had greater correlation with these parameters than Lund-Mackay scoring. Conclusion: Volumetric scoring exhibited higher degree of correlation than Lund-Mackay scoring when comparing improvement in CT score with improvement in score for symptoms, endoscopic exam, and quality of life in this group of patients who received beneficial medical treatment for CRS.

KW - Computed tomography

KW - Computer-assisted image analysis

KW - Endoscopy

KW - Lund-Mackay

KW - Quality of life

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JO - International Forum of Allergy and Rhinology

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ER -

Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: Clinical correlations and comparison to Lund-Mackay scoring

Abstract

Keywords

ASJC Scopus subject areas

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