Three-dimensional sonographic assessment of placental volume and vascularization in pregnancies complicated by hypertensive disorders

Eduardo Jorge De Almeida Pimenta, Carla Fagundes Silva De Paula, Juliana Alvares Duarte Bonini Campos, Karin Anneliese Fox, Rossana Francisco, Rodrigo Ruano, Marcelo Zugaib

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: The purpose of this study was to evaluate the association between placental volumes, placental vascularity, and hypertensive disorders in pregnancy. Methods: A prospective case-control study was conducted between April 2011 and July 2012. Placental volumes and vascularity were evaluated by 3-dimensional sonographic, 3-dimensional power Doppler histographic, and 2-dimensional color Doppler studies. Pregnant women were classified as normotensive or hypertensive and stratified by the nature of their hypertensive disorders. The following variables were evaluated: observed-to-expected placental volume ratio, placental volume-to-estimated fetal weight ratio, placental vascular indices, and pulsatility indices of the right and left uterine and umbilical arteries. Results: Sixty-six healthy pregnant women and 62 pregnant women with hypertensive disorders were evaluated (matched by maternal age, gestational age at sonography, and parity). Placental volumes were not reduced in pregnancy in women with hypertensive disorders (P >.05). Conversely, reduced placental vascularization indices (vascularization index and vascularization-flow index) were observed in pregnancies complicated by hypertensive disorders (P <.01; P <.01), especially in patients with superimposed preeclampsia (P =.04; P =.02). A weak correlation was observed between placental volumes, placental vascular indices, and Doppler studies of the uterine and umbilical arteries. Conclusions: Pregnancies complicated by hypertensive disorders are associated with reduced placental vascularity but not with reduced placental volumes. These findings are independent of changes in uterine artery Doppler studies. Future studies of the prediction of preeclampsia may focus on placental vascularity in combination with results of Doppler studies of the uterine arteries.

Original languageEnglish (US)
Pages (from-to)483-491
Number of pages9
JournalJournal of Ultrasound in Medicine
Volume33
Issue number3
DOIs
StatePublished - Mar 1 2014
Externally publishedYes

Fingerprint

Uterine Artery
Pregnant Women
Pregnancy
Umbilical Arteries
Pre-Eclampsia
Blood Vessels
Fetal Weight
Maternal Age
Parity
Gestational Age
Case-Control Studies
Ultrasonography
Color

Keywords

  • 3-dimensional power doppler sonography
  • 3-dimensional sonography
  • Arterial hypertension
  • Doppler study
  • Obstetric ultrasound
  • Placental size
  • Placental vascularity
  • Placental volume
  • Preeclampsia
  • Pregnancy
  • Umbilical arteries
  • Uterine arteries

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Three-dimensional sonographic assessment of placental volume and vascularization in pregnancies complicated by hypertensive disorders. / De Almeida Pimenta, Eduardo Jorge; De Paula, Carla Fagundes Silva; Campos, Juliana Alvares Duarte Bonini; Fox, Karin Anneliese; Francisco, Rossana; Ruano, Rodrigo; Zugaib, Marcelo.

In: Journal of Ultrasound in Medicine, Vol. 33, No. 3, 01.03.2014, p. 483-491.

Research output: Contribution to journalArticle

De Almeida Pimenta, Eduardo Jorge ; De Paula, Carla Fagundes Silva ; Campos, Juliana Alvares Duarte Bonini ; Fox, Karin Anneliese ; Francisco, Rossana ; Ruano, Rodrigo ; Zugaib, Marcelo. / Three-dimensional sonographic assessment of placental volume and vascularization in pregnancies complicated by hypertensive disorders. In: Journal of Ultrasound in Medicine. 2014 ; Vol. 33, No. 3. pp. 483-491.
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abstract = "Objectives: The purpose of this study was to evaluate the association between placental volumes, placental vascularity, and hypertensive disorders in pregnancy. Methods: A prospective case-control study was conducted between April 2011 and July 2012. Placental volumes and vascularity were evaluated by 3-dimensional sonographic, 3-dimensional power Doppler histographic, and 2-dimensional color Doppler studies. Pregnant women were classified as normotensive or hypertensive and stratified by the nature of their hypertensive disorders. The following variables were evaluated: observed-to-expected placental volume ratio, placental volume-to-estimated fetal weight ratio, placental vascular indices, and pulsatility indices of the right and left uterine and umbilical arteries. Results: Sixty-six healthy pregnant women and 62 pregnant women with hypertensive disorders were evaluated (matched by maternal age, gestational age at sonography, and parity). Placental volumes were not reduced in pregnancy in women with hypertensive disorders (P >.05). Conversely, reduced placental vascularization indices (vascularization index and vascularization-flow index) were observed in pregnancies complicated by hypertensive disorders (P <.01; P <.01), especially in patients with superimposed preeclampsia (P =.04; P =.02). A weak correlation was observed between placental volumes, placental vascular indices, and Doppler studies of the uterine and umbilical arteries. Conclusions: Pregnancies complicated by hypertensive disorders are associated with reduced placental vascularity but not with reduced placental volumes. These findings are independent of changes in uterine artery Doppler studies. Future studies of the prediction of preeclampsia may focus on placental vascularity in combination with results of Doppler studies of the uterine arteries.",
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AU - De Almeida Pimenta, Eduardo Jorge

AU - De Paula, Carla Fagundes Silva

AU - Campos, Juliana Alvares Duarte Bonini

AU - Fox, Karin Anneliese

AU - Francisco, Rossana

AU - Ruano, Rodrigo

AU - Zugaib, Marcelo

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N2 - Objectives: The purpose of this study was to evaluate the association between placental volumes, placental vascularity, and hypertensive disorders in pregnancy. Methods: A prospective case-control study was conducted between April 2011 and July 2012. Placental volumes and vascularity were evaluated by 3-dimensional sonographic, 3-dimensional power Doppler histographic, and 2-dimensional color Doppler studies. Pregnant women were classified as normotensive or hypertensive and stratified by the nature of their hypertensive disorders. The following variables were evaluated: observed-to-expected placental volume ratio, placental volume-to-estimated fetal weight ratio, placental vascular indices, and pulsatility indices of the right and left uterine and umbilical arteries. Results: Sixty-six healthy pregnant women and 62 pregnant women with hypertensive disorders were evaluated (matched by maternal age, gestational age at sonography, and parity). Placental volumes were not reduced in pregnancy in women with hypertensive disorders (P >.05). Conversely, reduced placental vascularization indices (vascularization index and vascularization-flow index) were observed in pregnancies complicated by hypertensive disorders (P <.01; P <.01), especially in patients with superimposed preeclampsia (P =.04; P =.02). A weak correlation was observed between placental volumes, placental vascular indices, and Doppler studies of the uterine and umbilical arteries. Conclusions: Pregnancies complicated by hypertensive disorders are associated with reduced placental vascularity but not with reduced placental volumes. These findings are independent of changes in uterine artery Doppler studies. Future studies of the prediction of preeclampsia may focus on placental vascularity in combination with results of Doppler studies of the uterine arteries.

AB - Objectives: The purpose of this study was to evaluate the association between placental volumes, placental vascularity, and hypertensive disorders in pregnancy. Methods: A prospective case-control study was conducted between April 2011 and July 2012. Placental volumes and vascularity were evaluated by 3-dimensional sonographic, 3-dimensional power Doppler histographic, and 2-dimensional color Doppler studies. Pregnant women were classified as normotensive or hypertensive and stratified by the nature of their hypertensive disorders. The following variables were evaluated: observed-to-expected placental volume ratio, placental volume-to-estimated fetal weight ratio, placental vascular indices, and pulsatility indices of the right and left uterine and umbilical arteries. Results: Sixty-six healthy pregnant women and 62 pregnant women with hypertensive disorders were evaluated (matched by maternal age, gestational age at sonography, and parity). Placental volumes were not reduced in pregnancy in women with hypertensive disorders (P >.05). Conversely, reduced placental vascularization indices (vascularization index and vascularization-flow index) were observed in pregnancies complicated by hypertensive disorders (P <.01; P <.01), especially in patients with superimposed preeclampsia (P =.04; P =.02). A weak correlation was observed between placental volumes, placental vascular indices, and Doppler studies of the uterine and umbilical arteries. Conclusions: Pregnancies complicated by hypertensive disorders are associated with reduced placental vascularity but not with reduced placental volumes. These findings are independent of changes in uterine artery Doppler studies. Future studies of the prediction of preeclampsia may focus on placental vascularity in combination with results of Doppler studies of the uterine arteries.

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KW - Placental volume

KW - Preeclampsia

KW - Pregnancy

KW - Umbilical arteries

KW - Uterine arteries

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