Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement

Jinyuan Zhou, He Zhu, Michael Lim, Lindsay Blair, Alfredo Quinones-Hinojosa, Steven A. Messina, Charles G. Eberhart, Martin G. Pomper, John Laterra, Peter B. Barker, Peter C.M. Van Zijl, Jaishri O. Blakeley

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

Purpose To investigate the feasibility of a three-dimensional amide-proton-transfer (APT) imaging sequence with gradient- and spin-echo readouts at 3 Tesla in patients with high- or low-grade gliomas. Materials and Methods Fourteen patients with newly diagnosed gliomas were recruited. After B0 inhomogeneity correction on a voxel-by-voxel basis, APT-weighted images were reconstructed using a magnetization-transfer-ratio asymmetry at offsets of ±3.5 ppm with respect to the water resonance. Analysis of variance post hoc tests were used for statistical evaluations, and results were validated with pathology. Results In six patients with gadolinium-enhancing high-grade gliomas, enhancing tumors on the postcontrast T1-weighted images were consistently hyperintense on the APT-weighted images. Increased APT-weighted signal intensity was also clearly visible in two pathologically proven, high-grade gliomas without gadolinium enhancement. The average APT-weighted signal was significantly higher in the lesions than in the contralateral normal-appearing brain tissue (P < 0.001). In six low-grade gliomas, including two with gadolinium enhancement, APT-weighted imaging showed iso-intensity or mild punctate hyperintensity within all the lesions, which was significantly lower than that seen in the high-grade gliomas (P < 0.001). Conclusion The proposed three-dimensional APT imaging sequence can be incorporated into standard brain MRI protocols for patients with malignant gliomas. J. Magn. Reson. Imaging 2013;38:1119-1128. © 2013 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)1119-1128
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume38
Issue number5
DOIs
StatePublished - Nov 2013

Keywords

  • APT imaging
  • CEST imaging
  • gadolinium enhancement
  • glioma
  • tumor grade

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Zhou, J., Zhu, H., Lim, M., Blair, L., Quinones-Hinojosa, A., Messina, S. A., Eberhart, C. G., Pomper, M. G., Laterra, J., Barker, P. B., Van Zijl, P. C. M., & Blakeley, J. O. (2013). Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement. Journal of Magnetic Resonance Imaging, 38(5), 1119-1128. https://doi.org/10.1002/jmri.24067