Theory and practical use of Bayesian methods in interpreting clinical trial data: a narrative review

David Ferreira, Mael Barthoulot, Julien Pottecher, Klaus D. Torp, Pierre Diemunsch, Nicolas Meyer

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The critical reading of scientific articles is necessary for the daily practice of evidence-based medicine. Rigorous comprehension of statistical methods is essential, as reflected by the extensive use of statistics in the biomedical literature. In contrast to the customary frequentist approach, which never uses or gives the probability of a hypothesis, Bayesian theory uses probabilities for both hypotheses and data. This statistical approach is increasingly used for analyses of clinical trial data and for applied machine learning. The aim of this review is to compare general Bayesian concepts with frequentist methods to facilitate a better understanding of Bayesian theory for readers who are not familiar with this approach. The review is intended to be used in combination with a checklist we have devised for reading reports analysed by Bayesian methods. We compare and contrast the different approaches of Bayesian vs frequentist statistical methods by considering data from a clinical trial that lends itself to this comparative approach.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalBritish journal of anaesthesia
Volume125
Issue number2
DOIs
StatePublished - Aug 2020

Keywords

  • Bayesian methods
  • clinician
  • frequentist
  • randomised controlled trial
  • statistical analysis
  • theory

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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