The young brain and concussion: Imaging as a biomarker for diagnosis and prognosis

Esteban Toledo; Alyssa Lebel; Lino Becerra; Anna Minster; Clas Linnman; Nasim Maleki; David W. Dodick; David Borsook

doi:10.1016/j.neubiorev.2012.03.007

The young brain and concussion: Imaging as a biomarker for diagnosis and prognosis

Esteban Toledo, Alyssa Lebel, Lino Becerra, Anna Minster, Clas Linnman, Nasim Maleki, David W. Dodick, David Borsook

Neurology

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Concussion (mild traumatic brain injury (mTBI)) is a significant pediatric public health concern. Despite increased awareness, a comprehensive understanding of the acute and chronic effects of concussion on central nervous system structure and function remains incomplete. Here we review the definition, epidemiology, and sequelae of concussion within the developing brain, during childhood and adolescence, with current data derived from studies of pathophysiology and neuroimaging. These findings may contribute to a better understanding of the neurological consequences of traumatic brain injuries, which in turn, may lead to the development of brain biomarkers to improve identification, management and prognosis of pediatric patients suffering from concussion.

Original language	English (US)
Pages (from-to)	1510-1531
Number of pages	22
Journal	Neuroscience and Biobehavioral Reviews
Volume	36
Issue number	6
DOIs	https://doi.org/10.1016/j.neubiorev.2012.03.007
State	Published - Jul 2012

Keywords

Adolescents
Autonomic
Brain
Brain imaging
Children
Cognitive
Concussion
Cortex
FMRI
Hypothalamus
TBI

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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10.1016/j.neubiorev.2012.03.007

Cite this

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abstract = "Concussion (mild traumatic brain injury (mTBI)) is a significant pediatric public health concern. Despite increased awareness, a comprehensive understanding of the acute and chronic effects of concussion on central nervous system structure and function remains incomplete. Here we review the definition, epidemiology, and sequelae of concussion within the developing brain, during childhood and adolescence, with current data derived from studies of pathophysiology and neuroimaging. These findings may contribute to a better understanding of the neurological consequences of traumatic brain injuries, which in turn, may lead to the development of brain biomarkers to improve identification, management and prognosis of pediatric patients suffering from concussion.",

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AU - Toledo, Esteban

AU - Lebel, Alyssa

AU - Becerra, Lino

AU - Minster, Anna

AU - Linnman, Clas

AU - Maleki, Nasim

AU - Dodick, David W.

AU - Borsook, David

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The young brain and concussion: Imaging as a biomarker for diagnosis and prognosis

Abstract

Keywords

ASJC Scopus subject areas

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