The weight of obesity on the human immune response to vaccination

Scott D. Painter, Inna G. Ovsyannikova, Gregory A. Poland

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Despite the high success of protection against several infectious diseases through effective vaccines, some sub-populations have been observed to respond poorly to vaccines, putting them at increased risk for vaccine-preventable diseases. In particular, the limited data concerning the effect of obesity on vaccine immunogenicity and efficacy suggests that obesity is a factor that increases the likelihood of a poor vaccine-induced immune response. Obesity occurs through the deposition of excess lipids into adipose tissue through the production of adipocytes, and is defined as a body-mass index (BMI)≥30kg/m<sup>2</sup>. The immune system is adversely affected by obesity, and these "immune consequences" raise concern for the lack of vaccine-induced immunity in the obese patient requiring discussion of how this sub-population might be better protected.

Original languageEnglish (US)
Pages (from-to)4422-4429
Number of pages8
JournalVaccine
Volume33
Issue number36
DOIs
StatePublished - Aug 26 2015

Keywords

  • Communicable diseases
  • Immunity
  • Immunization
  • Obesity
  • Vaccination

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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    Painter, S. D., Ovsyannikova, I. G., & Poland, G. A. (2015). The weight of obesity on the human immune response to vaccination. Vaccine, 33(36), 4422-4429. https://doi.org/10.1016/j.vaccine.2015.06.101