The value of quantifying 18F-FDG uptake in thyroid nodules found incidentally on whole-body PET-CT

Trond V. Bogsrud, Dimitrios Karantanis, Mark A. Nathan, Brian P. Mullan, Gregory A. Wiseman, Douglas A. Collins, Jan Kasperbauer, Scott E. Strome, Carl C. Reading, Ian D Hay, Val Lowe

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To determine if quantification of [F]fluorodeoxyglucose (F-FDG) uptake in a thyroid nodule found incidentally on whole-body F-FDG positron emission tomography-computed tomography (PET-CT) can be used to discriminate between malignant and benign aetiology. METHODS: A retrospective review of all patients with focally high uptake in the thyroid as an incidental finding on F-FDG PET-CT from May 2003 through May 2006. The uptake in the nodules was quantified using the maximum standardized uptake value (SUVmax). The aetiology was determined by cytology and/or ultrasound, or on histopathology. RESULTS: Incidental focally high uptake was found in 79/7347 patients (1.1%). In 31/48 patients with adequate follow-up, a benign aetiology was determined. Median SUVmax for the benign group was 5.6, range 2.5-53. Malignancy was confirmed in 15/48 patients. The malignancies were papillary thyroid carcinoma in 12, metastasis from squamous cell carcinoma in one, and lymphoma in two. Median SUVmax for the malignant lesions was 6.4, range 3.5-16. Cytology suspicious for follicular carcinoma was found in 2/48 patients. No statistical difference (P=0.12) was found among the SUVmax between the benign and malignant groups. CONCLUSION: Focally high uptake of F-FDG in the thyroid as an incidental finding occurred in 1.1% of the patients. Malignancy was confirmed or was suspicious in 17/48 (35%) of the patients that had adequate follow-up. There was no significant difference in the SUVmax between benign and malignant nodules.

Original languageEnglish (US)
Pages (from-to)373-381
Number of pages9
JournalNuclear Medicine Communications
Volume28
Issue number5
DOIs
StatePublished - May 2007

Fingerprint

Thyroid Nodule
Fluorodeoxyglucose F18
Incidental Findings
Cell Biology
Thyroid Gland
Neoplasms
Positron Emission Tomography Computed Tomography
Squamous Cell Carcinoma
Lymphoma
Neoplasm Metastasis
Carcinoma

Keywords

  • F-FDG PET-CT
  • Standard uptake value (SUV) focal thyroid FDG uptake
  • Thyroid nodules

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

The value of quantifying 18F-FDG uptake in thyroid nodules found incidentally on whole-body PET-CT. / Bogsrud, Trond V.; Karantanis, Dimitrios; Nathan, Mark A.; Mullan, Brian P.; Wiseman, Gregory A.; Collins, Douglas A.; Kasperbauer, Jan; Strome, Scott E.; Reading, Carl C.; Hay, Ian D; Lowe, Val.

In: Nuclear Medicine Communications, Vol. 28, No. 5, 05.2007, p. 373-381.

Research output: Contribution to journalArticle

Bogsrud, TV, Karantanis, D, Nathan, MA, Mullan, BP, Wiseman, GA, Collins, DA, Kasperbauer, J, Strome, SE, Reading, CC, Hay, ID & Lowe, V 2007, 'The value of quantifying 18F-FDG uptake in thyroid nodules found incidentally on whole-body PET-CT', Nuclear Medicine Communications, vol. 28, no. 5, pp. 373-381. https://doi.org/10.1097/MNM.0b013e3280964eae
Bogsrud, Trond V. ; Karantanis, Dimitrios ; Nathan, Mark A. ; Mullan, Brian P. ; Wiseman, Gregory A. ; Collins, Douglas A. ; Kasperbauer, Jan ; Strome, Scott E. ; Reading, Carl C. ; Hay, Ian D ; Lowe, Val. / The value of quantifying 18F-FDG uptake in thyroid nodules found incidentally on whole-body PET-CT. In: Nuclear Medicine Communications. 2007 ; Vol. 28, No. 5. pp. 373-381.
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abstract = "OBJECTIVE: To determine if quantification of [F]fluorodeoxyglucose (F-FDG) uptake in a thyroid nodule found incidentally on whole-body F-FDG positron emission tomography-computed tomography (PET-CT) can be used to discriminate between malignant and benign aetiology. METHODS: A retrospective review of all patients with focally high uptake in the thyroid as an incidental finding on F-FDG PET-CT from May 2003 through May 2006. The uptake in the nodules was quantified using the maximum standardized uptake value (SUVmax). The aetiology was determined by cytology and/or ultrasound, or on histopathology. RESULTS: Incidental focally high uptake was found in 79/7347 patients (1.1{\%}). In 31/48 patients with adequate follow-up, a benign aetiology was determined. Median SUVmax for the benign group was 5.6, range 2.5-53. Malignancy was confirmed in 15/48 patients. The malignancies were papillary thyroid carcinoma in 12, metastasis from squamous cell carcinoma in one, and lymphoma in two. Median SUVmax for the malignant lesions was 6.4, range 3.5-16. Cytology suspicious for follicular carcinoma was found in 2/48 patients. No statistical difference (P=0.12) was found among the SUVmax between the benign and malignant groups. CONCLUSION: Focally high uptake of F-FDG in the thyroid as an incidental finding occurred in 1.1{\%} of the patients. Malignancy was confirmed or was suspicious in 17/48 (35{\%}) of the patients that had adequate follow-up. There was no significant difference in the SUVmax between benign and malignant nodules.",
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T1 - The value of quantifying 18F-FDG uptake in thyroid nodules found incidentally on whole-body PET-CT

AU - Bogsrud, Trond V.

AU - Karantanis, Dimitrios

AU - Nathan, Mark A.

AU - Mullan, Brian P.

AU - Wiseman, Gregory A.

AU - Collins, Douglas A.

AU - Kasperbauer, Jan

AU - Strome, Scott E.

AU - Reading, Carl C.

AU - Hay, Ian D

AU - Lowe, Val

PY - 2007/5

Y1 - 2007/5

N2 - OBJECTIVE: To determine if quantification of [F]fluorodeoxyglucose (F-FDG) uptake in a thyroid nodule found incidentally on whole-body F-FDG positron emission tomography-computed tomography (PET-CT) can be used to discriminate between malignant and benign aetiology. METHODS: A retrospective review of all patients with focally high uptake in the thyroid as an incidental finding on F-FDG PET-CT from May 2003 through May 2006. The uptake in the nodules was quantified using the maximum standardized uptake value (SUVmax). The aetiology was determined by cytology and/or ultrasound, or on histopathology. RESULTS: Incidental focally high uptake was found in 79/7347 patients (1.1%). In 31/48 patients with adequate follow-up, a benign aetiology was determined. Median SUVmax for the benign group was 5.6, range 2.5-53. Malignancy was confirmed in 15/48 patients. The malignancies were papillary thyroid carcinoma in 12, metastasis from squamous cell carcinoma in one, and lymphoma in two. Median SUVmax for the malignant lesions was 6.4, range 3.5-16. Cytology suspicious for follicular carcinoma was found in 2/48 patients. No statistical difference (P=0.12) was found among the SUVmax between the benign and malignant groups. CONCLUSION: Focally high uptake of F-FDG in the thyroid as an incidental finding occurred in 1.1% of the patients. Malignancy was confirmed or was suspicious in 17/48 (35%) of the patients that had adequate follow-up. There was no significant difference in the SUVmax between benign and malignant nodules.

AB - OBJECTIVE: To determine if quantification of [F]fluorodeoxyglucose (F-FDG) uptake in a thyroid nodule found incidentally on whole-body F-FDG positron emission tomography-computed tomography (PET-CT) can be used to discriminate between malignant and benign aetiology. METHODS: A retrospective review of all patients with focally high uptake in the thyroid as an incidental finding on F-FDG PET-CT from May 2003 through May 2006. The uptake in the nodules was quantified using the maximum standardized uptake value (SUVmax). The aetiology was determined by cytology and/or ultrasound, or on histopathology. RESULTS: Incidental focally high uptake was found in 79/7347 patients (1.1%). In 31/48 patients with adequate follow-up, a benign aetiology was determined. Median SUVmax for the benign group was 5.6, range 2.5-53. Malignancy was confirmed in 15/48 patients. The malignancies were papillary thyroid carcinoma in 12, metastasis from squamous cell carcinoma in one, and lymphoma in two. Median SUVmax for the malignant lesions was 6.4, range 3.5-16. Cytology suspicious for follicular carcinoma was found in 2/48 patients. No statistical difference (P=0.12) was found among the SUVmax between the benign and malignant groups. CONCLUSION: Focally high uptake of F-FDG in the thyroid as an incidental finding occurred in 1.1% of the patients. Malignancy was confirmed or was suspicious in 17/48 (35%) of the patients that had adequate follow-up. There was no significant difference in the SUVmax between benign and malignant nodules.

KW - F-FDG PET-CT

KW - Standard uptake value (SUV) focal thyroid FDG uptake

KW - Thyroid nodules

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