TY - JOUR
T1 - The Value of Extent of Resection of Glioblastomas
T2 - Clinical Evidence and Current Approach
AU - Almeida, Joao Paulo
AU - Chaichana, Kaisorn L.
AU - Rincon-Torroella, Jordina
AU - Quinones-Hinojosa, Alfredo
N1 - Funding Information:
Research reported in this publication was supported by the National Institutes of Health under award number R01NS070024. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Funding Information:
Jordina Rincon-Torroella is funded by the Grant Fundació “La Caixa” for postgraduate studies.
Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2015/2
Y1 - 2015/2
N2 - Glioblastomas (GBM), one of the most common tumors of the central nervous system, are associated with poor prognosis, even with all the scientific development of the last decades. Individual survival, however, is not homogenous among GBM patients, and multiple factors are related to their outcome, including age, biological characteristics of the tumor, and extent of treatment. Extent of resection (EOR) plays a major role as an independent modifiable factor associated with improved overall and progression-free survival. Achievement of maximal safe resection, removing as much as possible the tumor while preserving the neurological function, is the main goal of the current surgical treatment of GBM. To reach this objective, different technologies and surgical techniques have been introduced in neuro-oncology surgery, including functional neuronavigation systems, ultrasound surgery, intraoperative MRI scan, and intraoperative cortical and subcortical mapping techniques. In the current manuscript, we examine the impact of EOR on the prognosis of GBM patients and the benefits and limitations of modern adjuvant techniques used for resection of these lesions.
AB - Glioblastomas (GBM), one of the most common tumors of the central nervous system, are associated with poor prognosis, even with all the scientific development of the last decades. Individual survival, however, is not homogenous among GBM patients, and multiple factors are related to their outcome, including age, biological characteristics of the tumor, and extent of treatment. Extent of resection (EOR) plays a major role as an independent modifiable factor associated with improved overall and progression-free survival. Achievement of maximal safe resection, removing as much as possible the tumor while preserving the neurological function, is the main goal of the current surgical treatment of GBM. To reach this objective, different technologies and surgical techniques have been introduced in neuro-oncology surgery, including functional neuronavigation systems, ultrasound surgery, intraoperative MRI scan, and intraoperative cortical and subcortical mapping techniques. In the current manuscript, we examine the impact of EOR on the prognosis of GBM patients and the benefits and limitations of modern adjuvant techniques used for resection of these lesions.
KW - Glioblastomas
KW - Intraoperative magnetic resonance imaging
KW - Intraoperative mapping
KW - Prognosis
KW - Resection
KW - Surgery
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84924862661&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924862661&partnerID=8YFLogxK
U2 - 10.1007/s11910-014-0517-x
DO - 10.1007/s11910-014-0517-x
M3 - Review article
C2 - 25467408
AN - SCOPUS:84924862661
SN - 1528-4042
VL - 15
JO - Current Neurology and Neuroscience Reports
JF - Current Neurology and Neuroscience Reports
IS - 2
ER -