The use of quantitative proteomics towards biomarker discovery in lung squamous cell carcinoma

Timothy G. Whitsett; Landon J. Inge; Nhan L. Tran

doi:10.3978/j.issn.2218-6751.2013.10.17

The use of quantitative proteomics towards biomarker discovery in lung squamous cell carcinoma

Timothy G. Whitsett, Landon J. Inge, Nhan L. Tran

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The high mortality rate in advanced lung cancer, due to a preponderance of tumors discovered at advanced stage, demands the discovery and clinical validation of biomarkers for diagnosing early stage disease. Quantitative proteomics technologies are capable of identifying protein biomarkers with diagnostic, prognostic, and predictive value. Recent works have demonstrated the utility in using quantitative proteomics across normal, pre-cancerous, and cancerous lesions towards the discovery of biomarkers for early stage lung cancer, as well as discovering novel mechanisms of lung carcinogenesis.

Original language	English (US)
Pages (from-to)	457-460
Number of pages	4
Journal	Translational Lung Cancer Research
Volume	2
Issue number	6
DOIs	https://doi.org/10.3978/j.issn.2218-6751.2013.10.17
State	Published - 2013

Keywords

Glutathione s-transferase pi 1 (GSTP1)
Isobaric tags for relative and absolute quantitation (iTRAQ)
Lung squamous cell carcinoma
Proteomics

ASJC Scopus subject areas

Oncology

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10.3978/j.issn.2218-6751.2013.10.17

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title = "The use of quantitative proteomics towards biomarker discovery in lung squamous cell carcinoma",

abstract = "The high mortality rate in advanced lung cancer, due to a preponderance of tumors discovered at advanced stage, demands the discovery and clinical validation of biomarkers for diagnosing early stage disease. Quantitative proteomics technologies are capable of identifying protein biomarkers with diagnostic, prognostic, and predictive value. Recent works have demonstrated the utility in using quantitative proteomics across normal, pre-cancerous, and cancerous lesions towards the discovery of biomarkers for early stage lung cancer, as well as discovering novel mechanisms of lung carcinogenesis.",

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AU - Inge, Landon J.

AU - Tran, Nhan L.

PY - 2013

Y1 - 2013

N2 - The high mortality rate in advanced lung cancer, due to a preponderance of tumors discovered at advanced stage, demands the discovery and clinical validation of biomarkers for diagnosing early stage disease. Quantitative proteomics technologies are capable of identifying protein biomarkers with diagnostic, prognostic, and predictive value. Recent works have demonstrated the utility in using quantitative proteomics across normal, pre-cancerous, and cancerous lesions towards the discovery of biomarkers for early stage lung cancer, as well as discovering novel mechanisms of lung carcinogenesis.

AB - The high mortality rate in advanced lung cancer, due to a preponderance of tumors discovered at advanced stage, demands the discovery and clinical validation of biomarkers for diagnosing early stage disease. Quantitative proteomics technologies are capable of identifying protein biomarkers with diagnostic, prognostic, and predictive value. Recent works have demonstrated the utility in using quantitative proteomics across normal, pre-cancerous, and cancerous lesions towards the discovery of biomarkers for early stage lung cancer, as well as discovering novel mechanisms of lung carcinogenesis.

KW - Glutathione s-transferase pi 1 (GSTP1)

KW - Isobaric tags for relative and absolute quantitation (iTRAQ)

KW - Lung squamous cell carcinoma

KW - Proteomics

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The use of quantitative proteomics towards biomarker discovery in lung squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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