The tumor microenvironment in follicular lymphoma

Zhi Zhang Yang, Stephen Maxted Ansell

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Like other B-cell lymphomas, the development and progression of follicular lymphoma (FL) involves complex interactions between the neoplastic B cells and the surrounding microenvironment. Malignant B cells can manipulate the microenvironment by skewing the differentiation of immune cells, attracting regulatory T cells or suppressive monocytes, or secreting cytokines that promote an immunosuppressive environment. The importance of the microenvironment in FL has been demonstrated using methodologies such as gene expression profiling, which has shown that the nature of the tumor microenvironment predicts survival in patients with FL and may influence the response to immunotherapy and risk of transformation. Strategies that both enhance an effective antitumor response and reverse immunosuppression and dysfunction will be essential in the development of effective immunotherapeutic approaches in this disease.

Original languageEnglish (US)
Pages (from-to)810-818
Number of pages9
JournalClinical Advances in Hematology and Oncology
Volume10
Issue number12
StatePublished - Dec 2012

Fingerprint

Follicular Lymphoma
Tumor Microenvironment
B-Lymphocytes
Cellular Microenvironment
Gene Expression Profiling
B-Cell Lymphoma
Regulatory T-Lymphocytes
Immunosuppressive Agents
Immunotherapy
Immunosuppression
Monocytes
Cell Differentiation
Cytokines
Survival

Keywords

  • Follicular helper T cells
  • Follicular lymphoma
  • Follicular regulatory T cells

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

The tumor microenvironment in follicular lymphoma. / Yang, Zhi Zhang; Ansell, Stephen Maxted.

In: Clinical Advances in Hematology and Oncology, Vol. 10, No. 12, 12.2012, p. 810-818.

Research output: Contribution to journalArticle

@article{112573a0f8c646db86b7982c87763afe,
title = "The tumor microenvironment in follicular lymphoma",
abstract = "Like other B-cell lymphomas, the development and progression of follicular lymphoma (FL) involves complex interactions between the neoplastic B cells and the surrounding microenvironment. Malignant B cells can manipulate the microenvironment by skewing the differentiation of immune cells, attracting regulatory T cells or suppressive monocytes, or secreting cytokines that promote an immunosuppressive environment. The importance of the microenvironment in FL has been demonstrated using methodologies such as gene expression profiling, which has shown that the nature of the tumor microenvironment predicts survival in patients with FL and may influence the response to immunotherapy and risk of transformation. Strategies that both enhance an effective antitumor response and reverse immunosuppression and dysfunction will be essential in the development of effective immunotherapeutic approaches in this disease.",
keywords = "Follicular helper T cells, Follicular lymphoma, Follicular regulatory T cells",
author = "Yang, {Zhi Zhang} and Ansell, {Stephen Maxted}",
year = "2012",
month = "12",
language = "English (US)",
volume = "10",
pages = "810--818",
journal = "Clinical Advances in Hematology and Oncology",
issn = "1543-0790",
publisher = "Millennium Medical Publishing, Inc.",
number = "12",

}

TY - JOUR

T1 - The tumor microenvironment in follicular lymphoma

AU - Yang, Zhi Zhang

AU - Ansell, Stephen Maxted

PY - 2012/12

Y1 - 2012/12

N2 - Like other B-cell lymphomas, the development and progression of follicular lymphoma (FL) involves complex interactions between the neoplastic B cells and the surrounding microenvironment. Malignant B cells can manipulate the microenvironment by skewing the differentiation of immune cells, attracting regulatory T cells or suppressive monocytes, or secreting cytokines that promote an immunosuppressive environment. The importance of the microenvironment in FL has been demonstrated using methodologies such as gene expression profiling, which has shown that the nature of the tumor microenvironment predicts survival in patients with FL and may influence the response to immunotherapy and risk of transformation. Strategies that both enhance an effective antitumor response and reverse immunosuppression and dysfunction will be essential in the development of effective immunotherapeutic approaches in this disease.

AB - Like other B-cell lymphomas, the development and progression of follicular lymphoma (FL) involves complex interactions between the neoplastic B cells and the surrounding microenvironment. Malignant B cells can manipulate the microenvironment by skewing the differentiation of immune cells, attracting regulatory T cells or suppressive monocytes, or secreting cytokines that promote an immunosuppressive environment. The importance of the microenvironment in FL has been demonstrated using methodologies such as gene expression profiling, which has shown that the nature of the tumor microenvironment predicts survival in patients with FL and may influence the response to immunotherapy and risk of transformation. Strategies that both enhance an effective antitumor response and reverse immunosuppression and dysfunction will be essential in the development of effective immunotherapeutic approaches in this disease.

KW - Follicular helper T cells

KW - Follicular lymphoma

KW - Follicular regulatory T cells

UR - http://www.scopus.com/inward/record.url?scp=84877964003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877964003&partnerID=8YFLogxK

M3 - Article

C2 - 23271353

AN - SCOPUS:84877964003

VL - 10

SP - 810

EP - 818

JO - Clinical Advances in Hematology and Oncology

JF - Clinical Advances in Hematology and Oncology

SN - 1543-0790

IS - 12

ER -