The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells

Paul R. Sanberg, David J. Eve, Alison E. Willing, Svitlana Garbuzova-Davis, Jun Tan, Cyndy D. Sanberg, Julie G. Allickson, L. Eduardo Cruz, Cesar V. Borlongan

Research output: Contribution to journalReview articlepeer-review

Abstract

Stem cell transplantation is a potentially important means of treatment for a number of disorders. Two different stem cell populations of interest are mononuclear umbilical cord blood cells and menstrual blood-derived stem cells. These cells are relatively easy to obtain, appear to be pluripotent, and are immunologically immature. These cells, particularly umbilical cord blood cells, have been studied as either single or multiple injections in a number of animal models of neurodegenerative disorders with some degree of success, including stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and Sanfilippo syndrome type B. Evidence of anti-inflammatory effects and secretion of specific cytokines and growth factors that promote cell survival, rather than cell replacement, have been detected in both transplanted cells.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalCell transplantation
Volume20
Issue number1
DOIs
StatePublished - 2011

Keywords

  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Menstrual-derived stem cells
  • Sanfilippo syndrome
  • Stroke
  • Umbilical cord blood

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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