The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant

Hong Chang, Stephen Sloan, Dan Li, Lihua Zhuang, Qi Long Yi, Christine I. Chen, Donna Reece, Kathy Chun, Alexander Keith Stewart

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

The frequency and prognostic relevance of translocations t(11;14) and t(4;14), the most common translocations involving the immunoglobulin heavy chain (IgH) gene in multiple myeloma (MM), were investigated in 128 patients treated with intensive chemotherapy and autologous stem cell transplant. Myeloma cells were identified by cytoplasmic light chain immunofluorescence combined with fluorescence in situ hybridization (cIg-FISH) for detection of translocations t(1;14) and t(4;14). Overall, t(11;14) was detected in 16 of 125 (12.8%) and t(4;14) in 15 of 120 (12.5%) patients. Progression-free and overall survivals were similar for patients with or without t(11;14). However, patients with t(4;14) had significantly shorter progression-free (median 9.9 months vs. 25.8 months; P = 0.0003) and overall survivals (median 18.3 months vs. 48.1 months; P < 0.0001) than patients without t(4;14). The t(4;14) was associated with IgA and t(11;14) with light chain MM. There was no association between the t(11;14) or t(4;14) and other biological parameters including age, gender, haemoglobin, β-2 microglobulin, C-reactive protein, calcium, creatinine, albumin, or the percentage of bone marrow plasma cells. Multivariate analysis identified t(4;14) as the only adverse prognostic factor for both progression-free survival and overall survival. Our results indicate that the t(4;14) detected by cIg-FISH is associated with a poor prognosis in MM patients receiving intensive chemotherapy and autotransplant.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalBritish Journal of Haematology
Volume125
Issue number1
DOIs
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Stem Cells
Transplants
Multiple Myeloma
Disease-Free Survival
Immunoglobulin Heavy Chain Genes
Light
Drug Therapy
Survival
Autografts
Plasma Cells
Fluorescence In Situ Hybridization
Bone Marrow Cells
C-Reactive Protein
Immunoglobulin A
Fluorescent Antibody Technique
Albumins
Creatinine
Hemoglobins
Multivariate Analysis
Calcium

Keywords

  • Fluorescence in situ hybridization
  • Immunoglobulin heavy chain translocation
  • Myeloma
  • Prognostic factor
  • Stem cell transplant

ASJC Scopus subject areas

  • Hematology

Cite this

The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant. / Chang, Hong; Sloan, Stephen; Li, Dan; Zhuang, Lihua; Yi, Qi Long; Chen, Christine I.; Reece, Donna; Chun, Kathy; Stewart, Alexander Keith.

In: British Journal of Haematology, Vol. 125, No. 1, 04.2004, p. 64-68.

Research output: Contribution to journalArticle

Chang, Hong ; Sloan, Stephen ; Li, Dan ; Zhuang, Lihua ; Yi, Qi Long ; Chen, Christine I. ; Reece, Donna ; Chun, Kathy ; Stewart, Alexander Keith. / The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant. In: British Journal of Haematology. 2004 ; Vol. 125, No. 1. pp. 64-68.
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abstract = "The frequency and prognostic relevance of translocations t(11;14) and t(4;14), the most common translocations involving the immunoglobulin heavy chain (IgH) gene in multiple myeloma (MM), were investigated in 128 patients treated with intensive chemotherapy and autologous stem cell transplant. Myeloma cells were identified by cytoplasmic light chain immunofluorescence combined with fluorescence in situ hybridization (cIg-FISH) for detection of translocations t(1;14) and t(4;14). Overall, t(11;14) was detected in 16 of 125 (12.8{\%}) and t(4;14) in 15 of 120 (12.5{\%}) patients. Progression-free and overall survivals were similar for patients with or without t(11;14). However, patients with t(4;14) had significantly shorter progression-free (median 9.9 months vs. 25.8 months; P = 0.0003) and overall survivals (median 18.3 months vs. 48.1 months; P < 0.0001) than patients without t(4;14). The t(4;14) was associated with IgA and t(11;14) with light chain MM. There was no association between the t(11;14) or t(4;14) and other biological parameters including age, gender, haemoglobin, β-2 microglobulin, C-reactive protein, calcium, creatinine, albumin, or the percentage of bone marrow plasma cells. Multivariate analysis identified t(4;14) as the only adverse prognostic factor for both progression-free survival and overall survival. Our results indicate that the t(4;14) detected by cIg-FISH is associated with a poor prognosis in MM patients receiving intensive chemotherapy and autotransplant.",
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AU - Chang, Hong

AU - Sloan, Stephen

AU - Li, Dan

AU - Zhuang, Lihua

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AU - Chen, Christine I.

AU - Reece, Donna

AU - Chun, Kathy

AU - Stewart, Alexander Keith

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