The sympathetic nervous system in diabetic neuropathy: a clinical and pathological study

Phillip Anson Low, J. C. Walsh, C. Y. Huang, J. G. McLeod

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

Tests of autonomic function were performed on 16 subjects with diabetic neuropathy. Abnormal sweating occurred in 10/10 (100 per cent), postural hypotension in 7/16 (44%), an abnormal Valsalva ratio in 7/11 (64%), and denervation hypersensitivity to phenylephrine in 2/8 (25%) of patients tested. A quantitative assessment of baroreceptor function was made. In diabetics there was a reduced resting heart period, heart period range and mean gain. Quantitative histologic studies were performed on the greater splanchnic nerves removed at autopsy from 9 control subjects and from 8 subjects with diabetic neuropathy. The fiber density was significantly reduced in the greater splanchnic nerve of diabetes. The predominant pathology on teased fiber preparations was that of demyelination. Disordered blood pressure control in diabetes correlated with the pathologic abnormalities in the sympathetic nervous system. Light and electronmicroscopic studies were performed on the sural nerves of 2 diabetic subjects with autonomic dysfunction. The predominant change was active axonal degeneration affecting mainly unmyelinated and small myelinated fibres.

Original languageEnglish (US)
Pages (from-to)341-356
Number of pages16
JournalBrain
Volume98
Issue number3
StatePublished - 1975
Externally publishedYes

Fingerprint

Sympathetic Nervous System
diabetic neuropathy
Splanchnic Nerves
sympathetic nervous system
Diabetic Neuropathies
Neurology
Nerve
nerve tissue
Diabetes
Fiber
Medical problems
Sural Nerve
Orthostatic Hypotension
Pressoreceptors
Sweating
diabetes
Fibers
Demyelinating Diseases
Phenylephrine
Denervation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Low, P. A., Walsh, J. C., Huang, C. Y., & McLeod, J. G. (1975). The sympathetic nervous system in diabetic neuropathy: a clinical and pathological study. Brain, 98(3), 341-356.

The sympathetic nervous system in diabetic neuropathy : a clinical and pathological study. / Low, Phillip Anson; Walsh, J. C.; Huang, C. Y.; McLeod, J. G.

In: Brain, Vol. 98, No. 3, 1975, p. 341-356.

Research output: Contribution to journalArticle

Low, PA, Walsh, JC, Huang, CY & McLeod, JG 1975, 'The sympathetic nervous system in diabetic neuropathy: a clinical and pathological study', Brain, vol. 98, no. 3, pp. 341-356.
Low, Phillip Anson ; Walsh, J. C. ; Huang, C. Y. ; McLeod, J. G. / The sympathetic nervous system in diabetic neuropathy : a clinical and pathological study. In: Brain. 1975 ; Vol. 98, No. 3. pp. 341-356.
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