The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête

M. L. Koloko Ngassie, C. A. Brandsma, R. Gosens, Y. S. Prakash, J. K. Burgess

Research output: Contribution to journalArticlepeer-review

Abstract

Beyond the structural changes, features including the dysregulation of endoplasmic reticulum (ER) stress response and increased senescence characterize the lung aging. ER stress response and senescence have been reported to be induced by factors like cigarette smoke. Therefore, deciphering the mechanisms underlying ER and senescent pathways interaction has become a challenge. In this review we highlight the known and unknown regarding ER stress response and senescence and their cross talk in aged lung.

Original languageEnglish (US)
Pages (from-to)150-159
Number of pages10
JournalPhysiology (Bethesda, Md.)
Volume36
Issue number3
DOIs
StatePublished - May 1 2021

Keywords

  • COPD
  • cellular senescence
  • endoplasmic reticulum stress
  • lung aging
  • unfolded protein response

ASJC Scopus subject areas

  • Physiology

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