TY - JOUR
T1 - The Spectrum of Diabetic Neuropathies
AU - Tracy, Jennifer A.
AU - Dyck, P. James B.
N1 - Funding Information:
Supported in part by a grant obtained from the National Institute of Neurological Disease and Stroke (NINDS 36797).
PY - 2008/2
Y1 - 2008/2
N2 - Diabetes mellitus is associated with many different neuropathic syndromes, ranging from a mild sensory disturbance as can be seen in a diabetic sensorimotor polyneuropathy, to the debilitating pain and weakness of a diabetic lumbosacral radiculoplexus neuropathy. The etiology of these syndromes has been studied extensively, and may vary among metabolic, compressive, and immunological bases for the different disorders, as well as mechanisms yet to be discovered. Many of these disorders of nerve appear to be separate conditions with different underlying mechanisms, and some are caused directly by diabetes mellitus, whereas others are associated with it but not caused by hyperglycemia. This article discusses a number of the more common disorders of nerve found with diabetes mellitus. It discusses the symmetrical neuropathies, particularly generalized diabetic polyneuropathy, and then the focal or asymmetrical types of diabetes-associated neuropathy.
AB - Diabetes mellitus is associated with many different neuropathic syndromes, ranging from a mild sensory disturbance as can be seen in a diabetic sensorimotor polyneuropathy, to the debilitating pain and weakness of a diabetic lumbosacral radiculoplexus neuropathy. The etiology of these syndromes has been studied extensively, and may vary among metabolic, compressive, and immunological bases for the different disorders, as well as mechanisms yet to be discovered. Many of these disorders of nerve appear to be separate conditions with different underlying mechanisms, and some are caused directly by diabetes mellitus, whereas others are associated with it but not caused by hyperglycemia. This article discusses a number of the more common disorders of nerve found with diabetes mellitus. It discusses the symmetrical neuropathies, particularly generalized diabetic polyneuropathy, and then the focal or asymmetrical types of diabetes-associated neuropathy.
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U2 - 10.1016/j.pmr.2007.10.010
DO - 10.1016/j.pmr.2007.10.010
M3 - Review article
C2 - 18194747
AN - SCOPUS:38049046967
SN - 1047-9651
VL - 19
SP - 1
EP - 26
JO - Physical Medicine and Rehabilitation Clinics of North America
JF - Physical Medicine and Rehabilitation Clinics of North America
IS - 1
ER -