The spectrum of autoimmune encephalopathies

Divyanshu Dubey, Anshudha Sawhney, Benjamin Greenberg, Andrea Lowden, Worthy Warnack, Pravin Khemani, Olaf Stuve, Steven Vernino

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Despite being a potentially reversible neurological condition, no clear guidelines for diagnosis or management of autoimmune encephalitis exist. In this study we analyzed clinical presentation, laboratory and imaging characteristics, and outcome of autoimmune encephalitis from three teaching hospitals. Non-paraneoplastic autoimmune encephalitis associated with antibodies against membrane antigens was the most common syndrome, especially in the pediatric population. Clinical outcome was better for patients with shorter latency from symptom onset to diagnosis and initiation of immunomodulation. Patients with underlying malignancy were less likely to respond well to immunomodulatory therapy. The clinical spectrum of autoimmune encephalitis is fairly broad, but prompt recognition and treatment often leads to excellent outcome.

Original languageEnglish (US)
Article number476194
Pages (from-to)93-97
Number of pages5
JournalJournal of neuroimmunology
Volume287
DOIs
StatePublished - Oct 15 2015
Externally publishedYes

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Keywords

  • Autoimmune
  • Encephalitis
  • Limbic encephalitis
  • Paraneoplastic
  • Seizure

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Dubey, D., Sawhney, A., Greenberg, B., Lowden, A., Warnack, W., Khemani, P., Stuve, O., & Vernino, S. (2015). The spectrum of autoimmune encephalopathies. Journal of neuroimmunology, 287, 93-97. [476194]. https://doi.org/10.1016/j.jneuroim.2015.08.014