The spectrum of acute cardiopulmonary events associated with multiple sclerosis exacerbations

Cristina Valencia-Sanchez, Brent P. Goodman, Jonathan L. Carter, Dean Marko Wingerchuk

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Diverse acute neurological injuries may cause acute cardiopulmonary events including neurogenic pulmonary edema (NPE) and neurogenic stunned myocardium (NSM). The mechanism is probably mediated by sympathetic nervous system activation. Focal central nervous system (CNS) lesions, such as demyelinating lesions in multiple sclerosis (MS), may also cause cardiopulmonary disturbances. We aim to review the acute cardiopulmonary events associated with MS relapses. We performed a literature search using PubMed, and selected case reports of acute cardiac and/or pulmonary events related to MS exacerbations. We grouped these events into three categories: 1) NPE with normal cardiac function; 2) NSM and Takotsubo cardiomyopathy (TTC); 3) coexisting myocardial dysfunction and pulmonary edema. In some cases, cardiac and pulmonary symptoms preceded the onset of neurological symptoms. The majority of cases were associated with acute demyelinating lesions located in the medulla. Acute brainstem MS relapses, with demyelinating lesions affecting the medulla, may cause acute cardiac and pulmonary events presumably secondary to sympathetic hyperstimulation. Specific regions in the medulla that regulate cardiac function, systemic blood pressure and pulmonary hydrostatic pressure seem to be responsible for these events.

Original languageEnglish (US)
JournalMultiple Sclerosis Journal
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Multiple Sclerosis
Pulmonary Edema
Myocardial Stunning
Lung
Takotsubo Cardiomyopathy
Recurrence
Hydrostatic Pressure
Sympathetic Nervous System
PubMed
Brain Stem
Central Nervous System
Blood Pressure
Wounds and Injuries

Keywords

  • medulla oblongata
  • Multiple sclerosis
  • neurogenic pulmonary edema
  • neurogenic stunned myocardium
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

The spectrum of acute cardiopulmonary events associated with multiple sclerosis exacerbations. / Valencia-Sanchez, Cristina; Goodman, Brent P.; Carter, Jonathan L.; Wingerchuk, Dean Marko.

In: Multiple Sclerosis Journal, 01.01.2019.

Research output: Contribution to journalArticle

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