The sodium-iodide symporter

C. H. Baker, John C. Morris

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant. Cloning and characterization of NIS has more recently allowed research into its use in non-thyroidal cancers through gene transfer for both diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalCurrent Drug Targets: Immune, Endocrine and Metabolic Disorders
Volume4
Issue number3
DOIs
StatePublished - Sep 2004

Fingerprint

Thyroid Gland
Active Biological Transport
Neoplasm Genes
Thyroid Diseases
Iodides
Organism Cloning
Blood Proteins
Membrane Proteins
Cell Membrane
Therapeutics
Research
sodium-iodide symporter

Keywords

  • Gene therapy
  • Sodium-iodide symporter
  • Thyroid neoplasms

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

Cite this

The sodium-iodide symporter. / Baker, C. H.; Morris, John C.

In: Current Drug Targets: Immune, Endocrine and Metabolic Disorders, Vol. 4, No. 3, 09.2004, p. 167-174.

Research output: Contribution to journalReview article

Baker, C. H. ; Morris, John C. / The sodium-iodide symporter. In: Current Drug Targets: Immune, Endocrine and Metabolic Disorders. 2004 ; Vol. 4, No. 3. pp. 167-174.
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