The sodium-iodide symporter

C. H. Baker, John C. Morris

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant. Cloning and characterization of NIS has more recently allowed research into its use in non-thyroidal cancers through gene transfer for both diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalCurrent Drug Targets: Immune, Endocrine and Metabolic Disorders
Volume4
Issue number3
DOIs
StatePublished - Sep 2004

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Keywords

  • Gene therapy
  • Sodium-iodide symporter
  • Thyroid neoplasms

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

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