The sodium-iodide symporter

C. H. Baker; John C. Morris

doi:10.2174/1568008043339839

The sodium-iodide symporter

C. H. Baker, John C. Morris

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant. Cloning and characterization of NIS has more recently allowed research into its use in non-thyroidal cancers through gene transfer for both diagnosis and treatment.

Original language	English (US)
Pages (from-to)	167-174
Number of pages	8
Journal	Current Drug Targets: Immune, Endocrine and Metabolic Disorders
Volume	4
Issue number	3
DOIs	https://doi.org/10.2174/1568008043339839
State	Published - Sep 2004

Keywords

Gene therapy
Sodium-iodide symporter
Thyroid neoplasms

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy

Access to Document

10.2174/1568008043339839

Cite this

@article{9810a3142a4747dda8ee9ebd23354b2f,

title = "The sodium-iodide symporter",

abstract = "The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant. Cloning and characterization of NIS has more recently allowed research into its use in non-thyroidal cancers through gene transfer for both diagnosis and treatment.",

keywords = "Gene therapy, Sodium-iodide symporter, Thyroid neoplasms",

author = "Baker, {C. H.} and Morris, {John C.}",

year = "2004",

month = sep,

doi = "10.2174/1568008043339839",

language = "English (US)",

volume = "4",

pages = "167--174",

journal = "Current Drug Targets: Immune, Endocrine and Metabolic Disorders",

issn = "1568-0088",

publisher = "Bentham Science Publishers B.V.",

number = "3",

}

TY - JOUR

T1 - The sodium-iodide symporter

AU - Baker, C. H.

AU - Morris, John C.

PY - 2004/9

Y1 - 2004/9

N2 - The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant. Cloning and characterization of NIS has more recently allowed research into its use in non-thyroidal cancers through gene transfer for both diagnosis and treatment.

AB - The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant. Cloning and characterization of NIS has more recently allowed research into its use in non-thyroidal cancers through gene transfer for both diagnosis and treatment.

KW - Gene therapy

KW - Sodium-iodide symporter

KW - Thyroid neoplasms

UR - http://www.scopus.com/inward/record.url?scp=4444291639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444291639&partnerID=8YFLogxK

U2 - 10.2174/1568008043339839

DO - 10.2174/1568008043339839

M3 - Review article

C2 - 15379719

AN - SCOPUS:4444291639

SN - 1568-0088

VL - 4

SP - 167

EP - 174

JO - Current Drug Targets: Immune, Endocrine and Metabolic Disorders

JF - Current Drug Targets: Immune, Endocrine and Metabolic Disorders

IS - 3

ER -

The sodium-iodide symporter

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this