The serum matrix metalloproteinase-9 level is an independent predictor of recurrence after ablation of persistent atrial fibrillation

Gang Wu, Shun Wang, Mian Cheng, Bin Peng, Jingjun Liang, He Huang, Xuejun Jiang, Lizhi Zhang, Bo Yang, Yong-Mei Cha, Hong Jiang, Congxin Huang

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

OBJECTIVES: This study investigated whether the serum matrix metalloproteinase-9 level is an independent predictor of recurrence after catheter ablation for persistent atrial fibrillation. METHODS: Fifty-eight consecutive patients with persistent atrial fibrillation were enrolled and underwent catheter ablation. The serum matrix metalloproteinase-9 level was detected before ablation and its relationship with recurrent arrhythmia was analyzed at the end of the follow-up. RESULTS: After a mean follow-up of 12.1±7.2 months, 21 (36.2%) patients had a recurrence of their arrhythmia after catheter ablation. At baseline, the matrix metalloproteinase-9 level was higher in the patients with recurrence than in the non-recurrent group (305.77±88.90 vs 234.41±93.36 ng/ml, respectively, p=0.006). A multivariate analysis showed that the matrix metalloproteinase-9 level was an independent predictor of arrhythmia recurrence, as was a history of atrial fibrillation and the diameter of the left atrium. CONCLUSION: The serum matrix metalloproteinase-9 level is an independent predictor of recurrent arrhythmia after catheter ablation in patients with persistent atrial fibrillation.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalClinics
Volume71
Issue number5
DOIs
StatePublished - May 1 2016

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Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Matrix metalloproteinase-9
  • Recurrence

ASJC Scopus subject areas

  • Medicine(all)

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