The secret origins and surprising fates of pancreas tumors

Jennifer M. Bailey, Kathleen E. DelGiorno, Howard C. Crawford

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDA) is especially deadly due to its recalcitrance to current therapies. One of the unique qualities of PDA that may contribute to this resistance is a striking plasticity of differentiation states starting at tumor formation and continuing throughout tumor progression, including metastasis. Here we explore the earliest steps of tumor formation and neoplastic progression and how this results in a fascinating cellular heterogeneity that is likely critical for tumor survival and progression. We hypothesize that reinforcing differentiation pathways run awry or targeting morphologically and molecularly distinct tumor stem-like cells may hold promise for future treatments of this deadly disease.

Original languageEnglish (US)
Article numberbgu056
JournalCarcinogenesis
Volume35
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • Acinar cell
  • Cell of origin
  • Transdifferentiation
  • Tuft cells
  • Tumorigenesis

ASJC Scopus subject areas

  • Cancer Research

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