The role of thrombolytics in acute and chronic occlusion of the hand

Randall R. De Martino, Steven L. Moran

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Distal arm and hand ischemia from vessel thrombosis or embolism remains a difficult clinical challenge. The causes of ischemia are variable and include connective tissue disease, embolism, atherosclerosis, and iatrogenic etiology. Although reports are limited, treatment with catheter-directed thrombolysis has favorable results in cases of acute thrombosis, with most patients (80%) demonstrating improvement. Digital amputation rates are less than 10% and the hand is often salvaged. Bleeding and access-site complications remain prevalent in patients undergoing intra-arterial thrombolysis. This review discusses etiology, treatment approaches, outcomes, and complications when thrombolytic therapy is used for distal arm and hand ischemia.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalHand Clinics
Issue number1
StatePublished - Feb 1 2015


  • Arterial occlusion
  • Catheter
  • Hand ischemia
  • Thrombolysis
  • Thrombolytics

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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