The role of the BCL-2 family of proteins in HIV-1 pathogenesis and persistence

Aswath P. Chandrasekar, Nathan W. Cummins, Andrew D. Badleya

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Advances in HIV-1 therapy have transformed the once fatal infection into a manageable, chronic condition, yet the search for a widely applicable approach to cure remains elusive. The ineffectiveness of antiretroviral therapy (ART) in reducing the size of the HIV-1 latent reservoir has prompted investigation into the mechanisms of HIV-1 latency and immune escape. One of the major regulators of apoptosis, the BCL-2 protein, alongside its homologous family members, is a major target of HIV-1-induced change. Recent studies have now demonstrated the association of this protein with cells that support proviral forms in the setting of latency and have helped identify BCL-2 as a novel and promising therapeutic target for HIV-1 therapy directed at possible cure. This review aims to systematically review the interactions of HIV-1 with BCL-2 and its homologs and to examine the possibility of using BCL-2 inhibitors in the study and elimination of the latent reservoir.

Original languageEnglish (US)
Article numbere00107-19
JournalClinical Microbiology Reviews
Volume33
Issue number1
DOIs
StatePublished - Jan 2020

Keywords

  • Antiapoptosis
  • Apoptosis
  • BCL-2 family
  • Human immunodeficiency virus

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

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