The role of 18F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor

Yucai Wang; Kari G. Rabe; Michael S. Bold; Min Shi; Curtis A. Hanson; Susan M. Schwager; Timothy G. Call; Saad S. Kenderian; Eli Muchtar; Suzanne R. Hayman; Amber B. Koehler; Amie L. Fonder; Asher A. Chanan-Khan; Daniel L. van Dyke; Susan L. Slager; Neil E. Kay; Wei Ding; Jose F. Leis; Sameer A. Parikh

doi:10.3324/HAEMATOL.2019.240564

The role of ¹⁸F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor

Yucai Wang, Kari G. Rabe, Michael S. Bold, Min Shi, Curtis A. Hanson, Susan M. Schwager, Timothy G. Call, Saad S. Kenderian, Eli Muchtar, Suzanne R. Hayman, Amber B. Koehler, Amie L. Fonder, Asher A. Chanan-Khan, Daniel L. van Dyke, Susan L. Slager, Neil E. Kay, Wei Ding, Jose F. Leis, Sameer A. Parikh

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Chronic lymphocytic leukemia (CLL) is a low grade B-cell malignancy. Approximately 2-10% of CLL can undergo Richter's transformation (RT) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL).^1-3 Management of RT is extremely challenging and the clinical outcome is dismal.⁴ In CLL patients with suspected disease progression, distinguishing between progressive CLL and RT is critically important, as the management and prognosis are different.

Original language	English (US)
Pages (from-to)	2675-2678
Number of pages	4
Journal	Haematologica
Volume	105
Issue number	5
DOIs	https://doi.org/10.3324/HAEMATOL.2019.240564
State	Published - Jan 2020

ASJC Scopus subject areas

Hematology

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10.3324/HAEMATOL.2019.240564

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Wang, Y., Rabe, K. G., Bold, M. S., Shi, M., Hanson, C. A., Schwager, S. M., Call, T. G., Kenderian, S. S., Muchtar, E., Hayman, S. R., Koehler, A. B., Fonder, A. L., Chanan-Khan, A. A., van Dyke, D. L., Slager, S. L., Kay, N. E., Ding, W., Leis, J. F., & Parikh, S. A. (2020). The role of ¹⁸F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor. Haematologica, 105(5), 2675-2678. https://doi.org/10.3324/HAEMATOL.2019.240564

Wang, Y, Rabe, KG, Bold, MS, Shi, M, Hanson, CA, Schwager, SM, Call, TG, Kenderian, SS, Muchtar, E, Hayman, SR, Koehler, AB, Fonder, AL, Chanan-Khan, AA, van Dyke, DL, Slager, SL , Kay, NE, Ding, W, Leis, JF & Parikh, SA 2020, 'The role of ¹⁸F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor', Haematologica, vol. 105, no. 5, pp. 2675-2678. https://doi.org/10.3324/HAEMATOL.2019.240564

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title = "The role of 18F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor",

abstract = "Chronic lymphocytic leukemia (CLL) is a low grade B-cell malignancy. Approximately 2-10% of CLL can undergo Richter's transformation (RT) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL).1-3 Management of RT is extremely challenging and the clinical outcome is dismal.4 In CLL patients with suspected disease progression, distinguishing between progressive CLL and RT is critically important, as the management and prognosis are different.",

author = "Yucai Wang and Rabe, {Kari G.} and Bold, {Michael S.} and Min Shi and Hanson, {Curtis A.} and Schwager, {Susan M.} and Call, {Timothy G.} and Kenderian, {Saad S.} and Eli Muchtar and Hayman, {Suzanne R.} and Koehler, {Amber B.} and Fonder, {Amie L.} and Chanan-Khan, {Asher A.} and {van Dyke}, {Daniel L.} and Slager, {Susan L.} and Kay, {Neil E.} and Wei Ding and Leis, {Jose F.} and Parikh, {Sameer A.}",

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doi = "10.3324/HAEMATOL.2019.240564",

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AU - Bold, Michael S.

AU - Shi, Min

AU - Hanson, Curtis A.

AU - Schwager, Susan M.

AU - Call, Timothy G.

AU - Kenderian, Saad S.

AU - Muchtar, Eli

AU - Hayman, Suzanne R.

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AU - Slager, Susan L.

AU - Kay, Neil E.

AU - Ding, Wei

AU - Leis, Jose F.

AU - Parikh, Sameer A.

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AB - Chronic lymphocytic leukemia (CLL) is a low grade B-cell malignancy. Approximately 2-10% of CLL can undergo Richter's transformation (RT) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL).1-3 Management of RT is extremely challenging and the clinical outcome is dismal.4 In CLL patients with suspected disease progression, distinguishing between progressive CLL and RT is critically important, as the management and prognosis are different.

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The role of ¹⁸F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor

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