The role of senescent cells in ageing

Research output: Contribution to journalArticle

670 Citations (Scopus)

Abstract

Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalNature
Volume509
Issue number7501
DOIs
StatePublished - 2014

Fingerprint

Cell Aging
Biological Phenomena
Cell Cycle Checkpoints
Pathology
Growth
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

The role of senescent cells in ageing. / Van Deursen, Jan.

In: Nature, Vol. 509, No. 7501, 2014, p. 439-446.

Research output: Contribution to journalArticle

Van Deursen, Jan. / The role of senescent cells in ageing. In: Nature. 2014 ; Vol. 509, No. 7501. pp. 439-446.
@article{cc602277b045471ba2d34f3911f96a49,
title = "The role of senescent cells in ageing",
abstract = "Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.",
author = "{Van Deursen}, Jan",
year = "2014",
doi = "10.1038/nature13193",
language = "English (US)",
volume = "509",
pages = "439--446",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7501",

}

TY - JOUR

T1 - The role of senescent cells in ageing

AU - Van Deursen, Jan

PY - 2014

Y1 - 2014

N2 - Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.

AB - Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.

UR - http://www.scopus.com/inward/record.url?scp=84901288438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901288438&partnerID=8YFLogxK

U2 - 10.1038/nature13193

DO - 10.1038/nature13193

M3 - Article

C2 - 24848057

AN - SCOPUS:84901288438

VL - 509

SP - 439

EP - 446

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7501

ER -