The role of senescent cells in ageing

Research output: Contribution to journalReview articlepeer-review

835 Scopus citations

Abstract

Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalNature
Volume509
Issue number7501
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • General

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