The role of selenium in the secretion of very-low-density lipoprotein in the isolated perfused rat liver

R. L. Scott, A. Kheshti, M. Heimberg, H. G. Wilcox, W. L. Stone

Research output: Contribution to journalArticlepeer-review

Abstract

A recirculating liver perfusion system was used to study the effects of dietary selenium (Se) on the hepatic secretion of very-low-density lipoprotein (VLDL). The perfusate from livers of rats fed on a Se-deficient diet incorporated about 50 % more [1-14C]oleic acid into triacylglycerol (TG) and cholesteryl esters (ChoEs) than did the perfusate from livers of rats fed on a Se-supplemented diet. Similarly, livers from rats fed the Se-deficient diet secreted more VLDL and incorporated about 60 %, more [1-14C]oleic acid into VLDL TG and ChoEs than did livers from rats fed the Se-supplemented diet. The liver perfusate from rats in the Se-deficient group also showed significantly decreased fatty acid oxidation. We conclude that Se is a potent modulator of lipoprotein metabolism. A primary action of Se deficiency appears to be a decrease in fatty acid oxidation and a stimulation of fatty acid esterification, leading to increased VLDL TG and ChoEs formation and secretion.

Original languageEnglish (US)
Pages (from-to)741-745
Number of pages5
JournalBiochemical Journal
Volume279
Issue number3
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'The role of selenium in the secretion of very-low-density lipoprotein in the isolated perfused rat liver'. Together they form a unique fingerprint.

Cite this