Abstract
Excitation-contraction coupling represents a cascade of events that connects the initiating signal, an elevation of cytosolic Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<inf>cyt</inf>), with the ensuing cross-bridge recruitment and cycling that underlies ATP-consuming mechanical work. Mitochondria are the power plant of the cell. An elevation in [Ca<sup>2+</sup>]<inf>cyt</inf> is followed by an increase in mitochondrial Ca<sup>2+</sup> ([Ca<sup>2+</sup>]<inf>mito</inf>). Moreover, an increase in [Ca<sup>2+</sup>]<inf>mito</inf> leads to an increase in ATP production. Therefore, the relationship between elevations in [Ca<sup>2+</sup>]<inf>cyt</inf> and [Ca<sup>2+</sup>]<inf>mito</inf> reflects a coupling between energy demand and energy supply. Accordingly, mitochondrial Ca<sup>2+</sup> regulation mediates excitation-energy coupling in ASM. To this end, mitochondrial movement within ASM cells may help couple ATP production to localized differences in energy demand.
Original language | English (US) |
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Title of host publication | Calcium Signaling In Airway Smooth Muscle Cells |
Publisher | Springer International Publishing |
Pages | 211-234 |
Number of pages | 24 |
Volume | 9783319013121 |
ISBN (Print) | 9783319013121, 3319013114, 9783319013114 |
DOIs | |
State | Published - Nov 1 2013 |
Keywords
- ATP
- Cytosolic Ca<sup>2+</sup>
- Excitation-Contraction Coupling
- Metabolism
- Mitochondrial Ca<sup>2+</sup>
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)