The role of mitochondria in calcium regulation in airway smooth muscle

Philippe Delmotte; Li Jia; Gary C Sieck

doi:10.1007/978-3-319-01312-1_11

The role of mitochondria in calcium regulation in airway smooth muscle

Philippe Delmotte, Li Jia, Gary C Sieck

Physiology & Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Excitation-contraction coupling represents a cascade of events that connects the initiating signal, an elevation of cytosolic Ca2+ concentration ([Ca2+]<inf>cyt</inf>), with the ensuing cross-bridge recruitment and cycling that underlies ATP-consuming mechanical work. Mitochondria are the power plant of the cell. An elevation in [Ca2+]<inf>cyt</inf> is followed by an increase in mitochondrial Ca2+ ([Ca2+]<inf>mito</inf>). Moreover, an increase in [Ca2+]<inf>mito</inf> leads to an increase in ATP production. Therefore, the relationship between elevations in [Ca2+]<inf>cyt</inf> and [Ca2+]<inf>mito</inf> reflects a coupling between energy demand and energy supply. Accordingly, mitochondrial Ca2+ regulation mediates excitation-energy coupling in ASM. To this end, mitochondrial movement within ASM cells may help couple ATP production to localized differences in energy demand.

Original language	English (US)
Title of host publication	Calcium Signaling In Airway Smooth Muscle Cells
Publisher	Springer International Publishing
Pages	211-234
Number of pages	24
Volume	9783319013121
ISBN (Print)	9783319013121, 3319013114, 9783319013114
DOIs	https://doi.org/10.1007/978-3-319-01312-1_11
State	Published - Nov 1 2013

Keywords

ATP
Cytosolic Ca2+
Excitation-Contraction Coupling
Metabolism
Mitochondrial Ca2+

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-3-319-01312-1_11

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Delmotte, P., Jia, L., & Sieck, G. C. (2013). The role of mitochondria in calcium regulation in airway smooth muscle. In Calcium Signaling In Airway Smooth Muscle Cells (Vol. 9783319013121, pp. 211-234). Springer International Publishing. https://doi.org/10.1007/978-3-319-01312-1_11

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AB - Excitation-contraction coupling represents a cascade of events that connects the initiating signal, an elevation of cytosolic Ca2+ concentration ([Ca2+]cyt), with the ensuing cross-bridge recruitment and cycling that underlies ATP-consuming mechanical work. Mitochondria are the power plant of the cell. An elevation in [Ca2+]cyt is followed by an increase in mitochondrial Ca2+ ([Ca2+]mito). Moreover, an increase in [Ca2+]mito leads to an increase in ATP production. Therefore, the relationship between elevations in [Ca2+]cyt and [Ca2+]mito reflects a coupling between energy demand and energy supply. Accordingly, mitochondrial Ca2+ regulation mediates excitation-energy coupling in ASM. To this end, mitochondrial movement within ASM cells may help couple ATP production to localized differences in energy demand.

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