The role of mitochondria in calcium regulation in airway smooth muscle

Philippe Delmotte; Li Jia; Gary C. Sieck

doi:10.1007/978-3-319-01312-1_11

The role of mitochondria in calcium regulation in airway smooth muscle

Philippe Delmotte, Li Jia, Gary C. Sieck

Physiology & Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Excitation-contraction coupling represents a cascade of events that connects the initiating signal, an elevation of cytosolic Ca²⁺ concentration ([Ca²⁺]_cyt), with the ensuing cross-bridge recruitment and cycling that underlies ATP-consuming mechanical work. Mitochondria are the power plant of the cell. An elevation in [Ca²⁺]_cyt is followed by an increase in mitochondrial Ca²⁺ ([Ca²⁺]_mito). Moreover, an increase in [Ca²⁺]_mito leads to an increase in ATP production. Therefore, the relationship between elevations in [Ca²⁺]_cyt and [Ca²⁺]_mito reflects a coupling between energy demand and energy supply. Accordingly, mitochondrial Ca²⁺ regulation mediates excitation-energy coupling in ASM. To this end, mitochondrial movement within ASM cells may help couple ATP production to localized differences in energy demand.

Original language	English (US)
Title of host publication	Calcium Signaling In Airway Smooth Muscle Cells
Publisher	Springer International Publishing
Pages	211-234
Number of pages	24
Volume	9783319013121
ISBN (Electronic)	9783319013121
ISBN (Print)	3319013114, 9783319013114
DOIs	https://doi.org/10.1007/978-3-319-01312-1_11
State	Published - Nov 1 2014

Keywords

ATP
Cytosolic Ca
Excitation-Contraction Coupling
Metabolism
Mitochondrial Ca

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/978-3-319-01312-1_11

Cite this

@inbook{395a09c6a24d45e9b229e31ec0e278b5,

title = "The role of mitochondria in calcium regulation in airway smooth muscle",

abstract = "Excitation-contraction coupling represents a cascade of events that connects the initiating signal, an elevation of cytosolic Ca2+ concentration ([Ca2+]cyt), with the ensuing cross-bridge recruitment and cycling that underlies ATP-consuming mechanical work. Mitochondria are the power plant of the cell. An elevation in [Ca2+]cyt is followed by an increase in mitochondrial Ca2+ ([Ca2+]mito). Moreover, an increase in [Ca2+]mito leads to an increase in ATP production. Therefore, the relationship between elevations in [Ca2+]cyt and [Ca2+]mito reflects a coupling between energy demand and energy supply. Accordingly, mitochondrial Ca2+ regulation mediates excitation-energy coupling in ASM. To this end, mitochondrial movement within ASM cells may help couple ATP production to localized differences in energy demand.",

keywords = "ATP, Cytosolic Ca, Excitation-Contraction Coupling, Metabolism, Mitochondrial Ca",

author = "Philippe Delmotte and Li Jia and Sieck, {Gary C.}",

year = "2014",

month = nov,

day = "1",

doi = "10.1007/978-3-319-01312-1_11",

language = "English (US)",

isbn = "3319013114",

volume = "9783319013121",

pages = "211--234",

booktitle = "Calcium Signaling In Airway Smooth Muscle Cells",

publisher = "Springer International Publishing",

}

TY - CHAP

T1 - The role of mitochondria in calcium regulation in airway smooth muscle

AU - Delmotte, Philippe

AU - Jia, Li

AU - Sieck, Gary C.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Excitation-contraction coupling represents a cascade of events that connects the initiating signal, an elevation of cytosolic Ca2+ concentration ([Ca2+]cyt), with the ensuing cross-bridge recruitment and cycling that underlies ATP-consuming mechanical work. Mitochondria are the power plant of the cell. An elevation in [Ca2+]cyt is followed by an increase in mitochondrial Ca2+ ([Ca2+]mito). Moreover, an increase in [Ca2+]mito leads to an increase in ATP production. Therefore, the relationship between elevations in [Ca2+]cyt and [Ca2+]mito reflects a coupling between energy demand and energy supply. Accordingly, mitochondrial Ca2+ regulation mediates excitation-energy coupling in ASM. To this end, mitochondrial movement within ASM cells may help couple ATP production to localized differences in energy demand.

AB - Excitation-contraction coupling represents a cascade of events that connects the initiating signal, an elevation of cytosolic Ca2+ concentration ([Ca2+]cyt), with the ensuing cross-bridge recruitment and cycling that underlies ATP-consuming mechanical work. Mitochondria are the power plant of the cell. An elevation in [Ca2+]cyt is followed by an increase in mitochondrial Ca2+ ([Ca2+]mito). Moreover, an increase in [Ca2+]mito leads to an increase in ATP production. Therefore, the relationship between elevations in [Ca2+]cyt and [Ca2+]mito reflects a coupling between energy demand and energy supply. Accordingly, mitochondrial Ca2+ regulation mediates excitation-energy coupling in ASM. To this end, mitochondrial movement within ASM cells may help couple ATP production to localized differences in energy demand.

KW - ATP

KW - Cytosolic Ca

KW - Excitation-Contraction Coupling

KW - Metabolism

KW - Mitochondrial Ca

UR - http://www.scopus.com/inward/record.url?scp=84930012609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930012609&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-01312-1_11

DO - 10.1007/978-3-319-01312-1_11

M3 - Chapter

AN - SCOPUS:84930012609

SN - 3319013114

SN - 9783319013114

VL - 9783319013121

SP - 211

EP - 234

BT - Calcium Signaling In Airway Smooth Muscle Cells

PB - Springer International Publishing

ER -

The role of mitochondria in calcium regulation in airway smooth muscle

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this