The role of mitochondria in calcium regulation in airway smooth muscle

Philippe Delmotte, Li Jia, Gary C Sieck

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Excitation-contraction coupling represents a cascade of events that connects the initiating signal, an elevation of cytosolic Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<inf>cyt</inf>), with the ensuing cross-bridge recruitment and cycling that underlies ATP-consuming mechanical work. Mitochondria are the power plant of the cell. An elevation in [Ca<sup>2+</sup>]<inf>cyt</inf> is followed by an increase in mitochondrial Ca<sup>2+</sup> ([Ca<sup>2+</sup>]<inf>mito</inf>). Moreover, an increase in [Ca<sup>2+</sup>]<inf>mito</inf> leads to an increase in ATP production. Therefore, the relationship between elevations in [Ca<sup>2+</sup>]<inf>cyt</inf> and [Ca<sup>2+</sup>]<inf>mito</inf> reflects a coupling between energy demand and energy supply. Accordingly, mitochondrial Ca<sup>2+</sup> regulation mediates excitation-energy coupling in ASM. To this end, mitochondrial movement within ASM cells may help couple ATP production to localized differences in energy demand.

Original languageEnglish (US)
Title of host publicationCalcium Signaling In Airway Smooth Muscle Cells
PublisherSpringer International Publishing
Pages211-234
Number of pages24
Volume9783319013121
ISBN (Print)9783319013121, 3319013114, 9783319013114
DOIs
StatePublished - Nov 1 2013

Keywords

  • ATP
  • Cytosolic Ca<sup>2+</sup>
  • Excitation-Contraction Coupling
  • Metabolism
  • Mitochondrial Ca<sup>2+</sup>

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Delmotte, P., Jia, L., & Sieck, G. C. (2013). The role of mitochondria in calcium regulation in airway smooth muscle. In Calcium Signaling In Airway Smooth Muscle Cells (Vol. 9783319013121, pp. 211-234). Springer International Publishing. https://doi.org/10.1007/978-3-319-01312-1_11