The Role of Interleukin-10 in the Pathophysiology of Preeclampsia

Hajrunisa Cubro, Sonu Kashyap, Meryl C. Nath, Allan W. Ackerman, Vesna D Garovic

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Purpose of Review: The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological imbalance that shifts the maternal immune response from one of tolerance towards one promoting chronic inflammation and endothelial dysfunction. As a key regulator of immunity, IL-10 not only has immunomodulatory activity, but also directly benefits vasculature and promotes successful cellular interactions at the maternal-fetal interface. Here we focus on the mechanisms by which the dysregulation of IL-10 may contribute to the pathophysiology of preeclampsia. Recent Findings: Dysregulation of IL-10 has been demonstrated in various animal models of preeclampsia. Decreased IL-10 production in both placenta and peripheral blood mononuclear cells has been reported in human studies, but with inconsistent results. Summary: The significance of IL-10 in preeclampsia has shifted from a key biomarker to one with therapeutic potential. As such, a better understanding of the role of this cytokine in the pathophysiology of preeclampsia is of paramount importance.

Original languageEnglish (US)
Article number36
JournalCurrent Hypertension Reports
Volume20
Issue number4
DOIs
StatePublished - Apr 1 2018

Keywords

  • Cytokines
  • Hypertension
  • Inflammation
  • Interleukin 10
  • Preeclampsia
  • Regulatory T cells
  • Vascular activity

ASJC Scopus subject areas

  • Internal Medicine

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