The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions

Joseph M. Gaballa; Manuel Bonfim Braga Neto; Guilherme Piovezani Ramos; Adebowale O. Bamidele; Michelle M. Gonzalez; Mary R. Sagstetter; Olga F. Sarmento; William A. Faubion

doi:10.3389/fimmu.2018.02955

The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions

Joseph M. Gaballa, Manuel Bonfim Braga Neto, Guilherme Piovezani Ramos, Adebowale O. Bamidele, Michelle M. Gonzalez, Mary R. Sagstetter, Olga F. Sarmento, William A. Faubion

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

T cell lineage decisions are critical for the development of proper immune responses to pathogens as well as important for the resolution of inflammatory responses. This differentiation process relies on a combination of intrinsic and extrinsic factors converging upon epigenetic regulation of transcriptional networks relevant to specific T cell lineages. As these biochemical modifications represent therapeutic opportunities in cancer biology and autoimmunity, implications of writers and readers of epigenetic marks to immune cell differentiation and function are highly relevant. Given the ready adoption of histone methyltransferase inhibitors in the clinic, we focus this review on the role of three histone modifying complexes: PRC-1, PRC-2, and G9A in modulating T cell fate decisions. Furthermore, we explore the role of long non-coding RNAs in regulating these processes, and discuss recent advances and challenges of implementing epigenetic therapies into clinical practice.

Original language	English (US)
Article number	2955
Journal	Frontiers in immunology
Volume	9
DOIs	https://doi.org/10.3389/fimmu.2018.02955
State	Published - Dec 13 2018

Keywords

EZH2
G9a
PRC1
PRC2
T cell
epigenetics
long non-coding RNAs

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3389/fimmu.2018.02955

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title = "The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions",

abstract = "T cell lineage decisions are critical for the development of proper immune responses to pathogens as well as important for the resolution of inflammatory responses. This differentiation process relies on a combination of intrinsic and extrinsic factors converging upon epigenetic regulation of transcriptional networks relevant to specific T cell lineages. As these biochemical modifications represent therapeutic opportunities in cancer biology and autoimmunity, implications of writers and readers of epigenetic marks to immune cell differentiation and function are highly relevant. Given the ready adoption of histone methyltransferase inhibitors in the clinic, we focus this review on the role of three histone modifying complexes: PRC-1, PRC-2, and G9A in modulating T cell fate decisions. Furthermore, we explore the role of long non-coding RNAs in regulating these processes, and discuss recent advances and challenges of implementing epigenetic therapies into clinical practice.",

keywords = "EZH2, G9a, PRC1, PRC2, T cell, epigenetics, long non-coding RNAs",

author = "Gaballa, {Joseph M.} and {Braga Neto}, {Manuel Bonfim} and Ramos, {Guilherme Piovezani} and Bamidele, {Adebowale O.} and Gonzalez, {Michelle M.} and Sagstetter, {Mary R.} and Sarmento, {Olga F.} and Faubion, {William A.}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2018 Gaballa, Braga Neto, Ramos, Bamidele, Gonzalez, Sagstetter, Sarmento and Faubion.",

year = "2018",

month = dec,

day = "13",

doi = "10.3389/fimmu.2018.02955",

language = "English (US)",

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AU - Gaballa, Joseph M.

AU - Braga Neto, Manuel Bonfim

AU - Ramos, Guilherme Piovezani

AU - Bamidele, Adebowale O.

AU - Gonzalez, Michelle M.

AU - Sagstetter, Mary R.

AU - Sarmento, Olga F.

AU - Faubion, William A.

PY - 2018/12/13

Y1 - 2018/12/13

N2 - T cell lineage decisions are critical for the development of proper immune responses to pathogens as well as important for the resolution of inflammatory responses. This differentiation process relies on a combination of intrinsic and extrinsic factors converging upon epigenetic regulation of transcriptional networks relevant to specific T cell lineages. As these biochemical modifications represent therapeutic opportunities in cancer biology and autoimmunity, implications of writers and readers of epigenetic marks to immune cell differentiation and function are highly relevant. Given the ready adoption of histone methyltransferase inhibitors in the clinic, we focus this review on the role of three histone modifying complexes: PRC-1, PRC-2, and G9A in modulating T cell fate decisions. Furthermore, we explore the role of long non-coding RNAs in regulating these processes, and discuss recent advances and challenges of implementing epigenetic therapies into clinical practice.

AB - T cell lineage decisions are critical for the development of proper immune responses to pathogens as well as important for the resolution of inflammatory responses. This differentiation process relies on a combination of intrinsic and extrinsic factors converging upon epigenetic regulation of transcriptional networks relevant to specific T cell lineages. As these biochemical modifications represent therapeutic opportunities in cancer biology and autoimmunity, implications of writers and readers of epigenetic marks to immune cell differentiation and function are highly relevant. Given the ready adoption of histone methyltransferase inhibitors in the clinic, we focus this review on the role of three histone modifying complexes: PRC-1, PRC-2, and G9A in modulating T cell fate decisions. Furthermore, we explore the role of long non-coding RNAs in regulating these processes, and discuss recent advances and challenges of implementing epigenetic therapies into clinical practice.

KW - EZH2

KW - G9a

KW - PRC1

KW - PRC2

KW - T cell

KW - epigenetics

KW - long non-coding RNAs

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The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions

Abstract

Keywords

ASJC Scopus subject areas

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