The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions

Joseph M. Gaballa, Manuel Bonfim Braga Neto, Guilherme Piovezani Ramos, Adebowale O. Bamidele, Michelle M. Gonzalez, Mary R. Sagstetter, Olga F. Sarmento, William A. Faubion

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

T cell lineage decisions are critical for the development of proper immune responses to pathogens as well as important for the resolution of inflammatory responses. This differentiation process relies on a combination of intrinsic and extrinsic factors converging upon epigenetic regulation of transcriptional networks relevant to specific T cell lineages. As these biochemical modifications represent therapeutic opportunities in cancer biology and autoimmunity, implications of writers and readers of epigenetic marks to immune cell differentiation and function are highly relevant. Given the ready adoption of histone methyltransferase inhibitors in the clinic, we focus this review on the role of three histone modifying complexes: PRC-1, PRC-2, and G9A in modulating T cell fate decisions. Furthermore, we explore the role of long non-coding RNAs in regulating these processes, and discuss recent advances and challenges of implementing epigenetic therapies into clinical practice.

Original languageEnglish (US)
Article number2955
Number of pages1
JournalFrontiers in immunology
Volume9
DOIs
StatePublished - 2018

Keywords

  • EZH2
  • G9a
  • PRC1
  • PRC2
  • T cell
  • epigenetics
  • long non-coding RNAs

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Gaballa, J. M., Braga Neto, M. B., Ramos, G. P., Bamidele, A. O., Gonzalez, M. M., Sagstetter, M. R., Sarmento, O. F., & Faubion, W. A. (2018). The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions. Frontiers in immunology, 9, [2955]. https://doi.org/10.3389/fimmu.2018.02955