The role of high-dose chemotherapy followed by peripheral blood stem cell transplantation for the treatment of multiple myeloma

Mustaqeem Siddiqui; Morie Gertz

doi:10.1080/10428190802084972

The role of high-dose chemotherapy followed by peripheral blood stem cell transplantation for the treatment of multiple myeloma

Mustaqeem Siddiqui, Morie Gertz

Hematology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The management of multiple myeloma has changed significantly over the past 10 years. The results obtained with conventional chemotherapy were disappointing; however the use of high dose therapy (HDT) and stem cell transplantation has significantly improved survival. Autologous, allogeneic and tandem transplantation, along with different conditioning regimens, have been studied in an attempt to optimise and further improve outcomes. This review summarises the role of stem cell transplantation in multiple myeloma. The advent of novel therapies such as thalidomide, lenalidomide and bortezomib have started to redefine the role of peripheral stem cell transplantation, however, further study is needed to better understand how to most effectively use these agents in multiple myeloma in conjunction with HDT.

Original language	English (US)
Pages (from-to)	1436-1451
Number of pages	16
Journal	Leukemia and Lymphoma
Volume	49
Issue number	8
DOIs	https://doi.org/10.1080/10428190802084972
State	Published - 2008

Keywords

Chemotherapeutic approaches
Clinical results
Hematopoietic stem cell transplantation
Multiple

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/10428190802084972

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abstract = "The management of multiple myeloma has changed significantly over the past 10 years. The results obtained with conventional chemotherapy were disappointing; however the use of high dose therapy (HDT) and stem cell transplantation has significantly improved survival. Autologous, allogeneic and tandem transplantation, along with different conditioning regimens, have been studied in an attempt to optimise and further improve outcomes. This review summarises the role of stem cell transplantation in multiple myeloma. The advent of novel therapies such as thalidomide, lenalidomide and bortezomib have started to redefine the role of peripheral stem cell transplantation, however, further study is needed to better understand how to most effectively use these agents in multiple myeloma in conjunction with HDT.",

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AB - The management of multiple myeloma has changed significantly over the past 10 years. The results obtained with conventional chemotherapy were disappointing; however the use of high dose therapy (HDT) and stem cell transplantation has significantly improved survival. Autologous, allogeneic and tandem transplantation, along with different conditioning regimens, have been studied in an attempt to optimise and further improve outcomes. This review summarises the role of stem cell transplantation in multiple myeloma. The advent of novel therapies such as thalidomide, lenalidomide and bortezomib have started to redefine the role of peripheral stem cell transplantation, however, further study is needed to better understand how to most effectively use these agents in multiple myeloma in conjunction with HDT.

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The role of high-dose chemotherapy followed by peripheral blood stem cell transplantation for the treatment of multiple myeloma

Abstract

Keywords

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