The role of estrogens in men and androgens in women

Sundeep Khosla, John P. Bilezikian

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

The past years several have witnessed a significant transformation in our understanding of sex steroid action in the male and female skeleton. Data from animal and human studies indicate that sex steroids have important skeletal effects in both genders. It seems from the in vivo human data that estrogen is likely more potent than testosterone in inhibiting bone resorption. Estrogen and testosterone appear to be important for maintaining bone formation. In addition, androgens clearly enhance bone size, likely through effects on periosteal bone formation. How much of this gender cross-talk at the physiological level is caused by "promiscuous" actions of sex steroids at the molecular level, with estrogen acting by way of the androgen receptor (and androgens via the estrogen receptor) is an interesting and important question, the answer to which may well provide additional surprises.

Original languageEnglish (US)
Pages (from-to)195-218
Number of pages24
JournalEndocrinology and Metabolism Clinics of North America
Volume32
Issue number1
DOIs
StatePublished - Feb 2003

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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