The role of endothelin in coronary atherosclerosis

V. Mathew, D. Hasdai, Amir Lerman

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

During the evolution of coronary atherosclerosis, growth factors, cytokines, and other molecules are involved in cell recruitment, migration, and proliferation. Endothelin is an endothelial-derived vasoconstrictor peptide that possesses mitogenic properties. In this review, current evidence is provided that suggest that endothelin fulfills proposed criteria to be considered an atherogenic peptide because of its mitogenic and proliferative properties, as well as its interactions with known atherogenic factors. In addition, a proposed role of endothelin in the evolution of atherosclerosis is outlined.

Original languageEnglish (US)
Pages (from-to)769-777
Number of pages9
JournalMayo Clinic Proceedings
Volume71
Issue number8
StatePublished - 1996

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Endothelins
Coronary Artery Disease
Peptides
Vasoconstrictor Agents
Cell Movement
Atherosclerosis
Intercellular Signaling Peptides and Proteins
Cell Proliferation
Cytokines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The role of endothelin in coronary atherosclerosis. / Mathew, V.; Hasdai, D.; Lerman, Amir.

In: Mayo Clinic Proceedings, Vol. 71, No. 8, 1996, p. 769-777.

Research output: Contribution to journalArticle

Mathew, V, Hasdai, D & Lerman, A 1996, 'The role of endothelin in coronary atherosclerosis', Mayo Clinic Proceedings, vol. 71, no. 8, pp. 769-777.
Mathew, V. ; Hasdai, D. ; Lerman, Amir. / The role of endothelin in coronary atherosclerosis. In: Mayo Clinic Proceedings. 1996 ; Vol. 71, No. 8. pp. 769-777.
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