The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain

Alma Y. Galvez-Contreras, Alfredo Quinones-Hinojosa, Oscar Gonzalez-Perez

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

In the adult brain, multipotent progenitor cells have been identified in three areas: the ventricular-subventricular zone (VZ-SVZ), adjacent to the striatal wall of the lateral ventricles, the subgranular zone (SGZ), located at the dentate gyrus of the hippocampus and the subcallosal zone (SCZ), located between the corpus callosum and the CA1 and CA2 regions of the hippocampus. The neural progenitor cells of these regions express the epidermal growth factor receptor (EGFR, ErbB-1 or HER1). EGF, the most important ligand for the EGFR, is a potent mitogenic agent that stimulates proliferation, survival, migration and differentiation into the oligodendrocyte lineage. Other ErbB receptors also activate several intracellular pathways for oligodendrocyte specification, migration and survival. However, the specific downstream pathways related to oligodendrogenesis and the hierarchic interaction among intracellular signaling cascades is not well-known. We summarize the current data regarding the role of EGFR and ErbB family signaling on neural stem cells and the downstream cascades involved in oligodendrogenesis in the neurogenic niches of the adult brain. Understanding the mechanisms that regulate proliferation, differentiation, migration of oligodendrocytes and myelination is of critical importance for the field of neurobiology and constitutes a crucial step in the design of stem-cell-based therapies for demyelinating diseases.

Original languageEnglish (US)
Article number258
JournalFrontiers in Cellular Neuroscience
Volume7
Issue numberDEC
DOIs
StatePublished - Dec 17 2013
Externally publishedYes

Fingerprint

Oligodendroglia
Stem Cells
Lateral Ventricles
Brain
Corpus Striatum
Parahippocampal Gyrus
Proteins
Neural Stem Cells
Neurobiology
Corpus Callosum
Dentate Gyrus
Demyelinating Diseases
Cell- and Tissue-Based Therapy
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Hippocampus
Ligands

Keywords

  • Epidermal growth factor
  • Myelin
  • Neural stem cell
  • NG2 glia
  • Oligodendrocyte
  • Platelet-derived growth factor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain. / Galvez-Contreras, Alma Y.; Quinones-Hinojosa, Alfredo; Gonzalez-Perez, Oscar.

In: Frontiers in Cellular Neuroscience, Vol. 7, No. DEC, 258, 17.12.2013.

Research output: Contribution to journalArticle

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