The relationship of bone blood flow, bone tracer deposition, and endosteal new bone formation

John C. McInnis, Richard A. Robb, Patrick J. Kelly

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Bilateral defects of 4.5 by 11 mm were made in the distal one-third of the tibias of eight dogs and unilaterally in four dogs. Bone blood flow was measured by 1-Ap washout, tracer deposition of 85Sr was determined, and extraction of 85Sr and [14C]sucrose was measured by the indicator-dilution technique. Endosteal new bone formation was determined by a combined tetracycline-microradiography method. There was a significant correlation between blood flow determined by washout (1-Ap determined over the area of healing bone) and endosteal new bone formation, p < 0.001, expressed as relationships (percent) of the area of new endosteal bone to the total area enclosed by the defect and the medullary cavity of the tibia, p < 0.001. This percentage ranged from 12% to 62% and was directly related to bone blood flow. This suggests that the increase in blood flow in new bone may be secondary to increased metabolic demands.

Original languageEnglish (US)
Pages (from-to)511-522
Number of pages12
JournalJournal of Laboratory and Clinical Medicine
Volume96
Issue number3
StatePublished - Jan 1 1980

Keywords

  • I-Ap
  • I-labeled 4-iodoantipyrine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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