The Relationship Between Clinical Factors and Gastrointestinal Dysmotility in Diabetes Mellitus

C. H. Kim, F. P. Kennedy, Michael Camilleri, A. R. Zinsmeister, D. J. Ballard

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Motility of the stomach and upper intestine was studied in 84 consecutive diabetic patients referred to the Mayo Clinic for evaluation of functional symptoms (nausea, vomiting, or epigastric pain in the absence of structural or mucosal abnormalities). Manometric abnormalities were found in 81 of 84 patients who successfully completed a 3‐hour fast and 2‐hour postprandial motility evaluation. Antral hypomotility was found in 9 patients, small intestinal dysmotility in 11, and gastric and small‐intestinal dysmotilities in 61. The most common abnormalities were the absence of a fed motility pattern after ingestion of the meal and the presence of abnormal intestinal bursts during the fasting period. Clinical factors such as type and duration of diabetes, fasting serum glucose and glycosylated hemoglobin levels, daily dose of insulin therapy, presence of autonomic neuropathy, peripheral neuropathy, retinopathy, and vascular disease were not significantly associated with the severity of gastrointestinal dysmotility. However, there was a significant association between the number of extraintestinal diabetic complications and the severity of gastrointestinal dysmotility (p < 0.05). We conclude that clinical factors, by and large, are not helpful in predicting the severity of gastrointestinal dysmotility among symptomatic diabetic patients.

Original languageEnglish (US)
Pages (from-to)268-272
Number of pages5
JournalNeurogastroenterology and Motility
Volume3
Issue number4
DOIs
StatePublished - 1991

Fingerprint

Diabetes Mellitus
Fasting
Stomach
Symptom Assessment
Glycosylated Hemoglobin A
Peripheral Nervous System Diseases
Diabetes Complications
Vascular Diseases
Nausea
Intestines
Vomiting
Meals
Eating
Insulin
Glucose
Pain
Serum
Therapeutics

Keywords

  • clinical factors
  • diabetes mellitus
  • gastrointestinal dysmotility

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

The Relationship Between Clinical Factors and Gastrointestinal Dysmotility in Diabetes Mellitus. / Kim, C. H.; Kennedy, F. P.; Camilleri, Michael; Zinsmeister, A. R.; Ballard, D. J.

In: Neurogastroenterology and Motility, Vol. 3, No. 4, 1991, p. 268-272.

Research output: Contribution to journalArticle

Kim, C. H. ; Kennedy, F. P. ; Camilleri, Michael ; Zinsmeister, A. R. ; Ballard, D. J. / The Relationship Between Clinical Factors and Gastrointestinal Dysmotility in Diabetes Mellitus. In: Neurogastroenterology and Motility. 1991 ; Vol. 3, No. 4. pp. 268-272.
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