The PsychENCODE project

Schahram Akbarian; Chunyu Liu; James A. Knowles; Flora M. Vaccarino; Peggy J. Farnham; Gregory E. Crawford; Andrew E. Jaffe; Dalila Pinto; Stella Dracheva; Daniel H. Geschwind; Jonathan Mill; Angus C. Nairn; Alexej Abyzov; Sirisha Pochareddy; Shyam Prabhakar; Sherman Weissman; Patrick F. Sullivan; Matthew W. State; Zhiping Weng; Mette A. Peters; Kevin P. White; Mark B. Gerstein; Anahita Amiri; Chris Armoskus; Allison E. Ashley-Koch; Taejeong Bae; Andrea Beckel-Mitchener; Benjamin P. Berman; Gerhard A. Coetzee; Gianfilippo Coppola; Nancy Francoeur; Menachem Fromer; Robert Gao; Kay Grennan; Jennifer Herstein; David H. Kavanagh; Nikolay A. Ivanov; Yan Jiang; Robert R. Kitchen; Alexey Kozlenkov; Marija Kundakovic; Mingfeng Li; Zhen Li; Shuang Liu; Lara M. Mangravite; Eugenio Mattei; Eirene Markenscoff-Papadimitriou; Fábio C.P. Navarro; Nicole North; Larsson Omberg; David Panchision; Neelroop Parikshak; Jeremie Poschmann; Amanda J. Price; Michael Purcaro; Timothy E. Reddy; Panos Roussos; Shannon Schreiner; Soraya Scuderi; Robert Sebra; Mikihito Shibata; Annie W. Shieh; Mario Skarica; Wenjie Sun; Vivek Swarup; Amber Thomas; Junko Tsuji; Harm Van Bakel; Daifeng Wang; Yongjun Wang; Kai Wang; Donna M. Werling; A. Jeremy Willsey; Heather Witt; Hyejung Won; Chloe C.Y. Wong; Gregory A. Wray; Emily Y. Wu; Xuming Xu; Lijing Yao; Geetha Senthil; Thomas Lehner; Pamela Sklar; Nenad Sestan

doi:10.1038/nn.4156

The PsychENCODE project

Schahram Akbarian, Chunyu Liu, James A. Knowles, Flora M. Vaccarino, Peggy J. Farnham, Gregory E. Crawford, Andrew E. Jaffe, Dalila Pinto, Stella Dracheva, Daniel H. Geschwind, Jonathan Mill, Angus C. Nairn, Alexej Abyzov, Sirisha Pochareddy, Shyam Prabhakar, Sherman Weissman, Patrick F. Sullivan, Matthew W. State, Zhiping Weng, Mette A. PetersKevin P. White, Mark B. Gerstein, Anahita Amiri, Chris Armoskus, Allison E. Ashley-Koch, Taejeong Bae, Andrea Beckel-Mitchener, Benjamin P. Berman, Gerhard A. Coetzee, Gianfilippo Coppola, Nancy Francoeur, Menachem Fromer, Robert Gao, Kay Grennan, Jennifer Herstein, David H. Kavanagh, Nikolay A. Ivanov, Yan Jiang, Robert R. Kitchen, Alexey Kozlenkov, Marija Kundakovic, Mingfeng Li, Zhen Li, Shuang Liu, Lara M. Mangravite, Eugenio Mattei, Eirene Markenscoff-Papadimitriou, Fábio C.P. Navarro, Nicole North, Larsson Omberg, David Panchision, Neelroop Parikshak, Jeremie Poschmann, Amanda J. Price, Michael Purcaro, Timothy E. Reddy, Panos Roussos, Shannon Schreiner, Soraya Scuderi, Robert Sebra, Mikihito Shibata, Annie W. Shieh, Mario Skarica, Wenjie Sun, Vivek Swarup, Amber Thomas, Junko Tsuji, Harm Van Bakel, Daifeng Wang, Yongjun Wang, Kai Wang, Donna M. Werling, A. Jeremy Willsey, Heather Witt, Hyejung Won, Chloe C.Y. Wong, Gregory A. Wray, Emily Y. Wu, Xuming Xu, Lijing Yao, Geetha Senthil, Thomas Lehner, Pamela Sklar, Nenad Sestan

Quantitative Health Sciences

Research output: Contribution to journal › Review article › peer-review

177 Scopus citations

Abstract

Recent research on disparate psychiatric disorders has implicated rare variants in genes involved in global gene regulation and chromatin modification, as well as many common variants located primarily in regulatory regions of the genome. Understanding precisely how these variants contribute to disease will require a deeper appreciation for the mechanisms of gene regulation in the developing and adult human brain. The PsychENCODE project aims to produce a public resource of multidimensional genomic data using tissue- and cell type-specific samples from approximately 1,000 phenotypically well-characterized, high-quality healthy and disease-affected human post-mortem brains, as well as functionally characterize disease-associated regulatory elements and variants in model systems. We are beginning with a focus on autism spectrum disorder, bipolar disorder and schizophrenia, and expect that this knowledge will apply to a wide variety of psychiatric disorders. This paper outlines the motivation and design of PsychENCODE.

Original language	English (US)
Pages (from-to)	1707-1712
Number of pages	6
Journal	Nature Neuroscience
Volume	18
Issue number	12
DOIs	https://doi.org/10.1038/nn.4156
State	Published - Nov 25 2015

ASJC Scopus subject areas

General Neuroscience

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10.1038/nn.4156

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Akbarian, S., Liu, C., Knowles, J. A., Vaccarino, F. M., Farnham, P. J., Crawford, G. E., Jaffe, A. E., Pinto, D., Dracheva, S., Geschwind, D. H., Mill, J., Nairn, A. C., Abyzov, A., Pochareddy, S., Prabhakar, S., Weissman, S., Sullivan, P. F., State, M. W., Weng, Z., ... Sestan, N. (2015). The PsychENCODE project. Nature Neuroscience, 18(12), 1707-1712. https://doi.org/10.1038/nn.4156

Akbarian, S, Liu, C, Knowles, JA, Vaccarino, FM, Farnham, PJ, Crawford, GE, Jaffe, AE, Pinto, D, Dracheva, S, Geschwind, DH, Mill, J, Nairn, AC, Abyzov, A, Pochareddy, S, Prabhakar, S, Weissman, S, Sullivan, PF, State, MW, Weng, Z, Peters, MA, White, KP, Gerstein, MB, Amiri, A, Armoskus, C, Ashley-Koch, AE, Bae, T, Beckel-Mitchener, A, Berman, BP, Coetzee, GA, Coppola, G, Francoeur, N, Fromer, M, Gao, R, Grennan, K, Herstein, J, Kavanagh, DH, Ivanov, NA, Jiang, Y, Kitchen, RR, Kozlenkov, A, Kundakovic, M, Li, M, Li, Z, Liu, S, Mangravite, LM, Mattei, E, Markenscoff-Papadimitriou, E, Navarro, FCP, North, N, Omberg, L, Panchision, D, Parikshak, N, Poschmann, J, Price, AJ, Purcaro, M, Reddy, TE, Roussos, P, Schreiner, S, Scuderi, S, Sebra, R, Shibata, M, Shieh, AW, Skarica, M, Sun, W, Swarup, V, Thomas, A, Tsuji, J, Van Bakel, H, Wang, D, Wang, Y, Wang, K, Werling, DM, Willsey, AJ, Witt, H, Won, H, Wong, CCY, Wray, GA, Wu, EY, Xu, X, Yao, L, Senthil, G, Lehner, T, Sklar, P & Sestan, N 2015, 'The PsychENCODE project', Nature Neuroscience, vol. 18, no. 12, pp. 1707-1712. https://doi.org/10.1038/nn.4156

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title = "The PsychENCODE project",

abstract = "Recent research on disparate psychiatric disorders has implicated rare variants in genes involved in global gene regulation and chromatin modification, as well as many common variants located primarily in regulatory regions of the genome. Understanding precisely how these variants contribute to disease will require a deeper appreciation for the mechanisms of gene regulation in the developing and adult human brain. The PsychENCODE project aims to produce a public resource of multidimensional genomic data using tissue- and cell type-specific samples from approximately 1,000 phenotypically well-characterized, high-quality healthy and disease-affected human post-mortem brains, as well as functionally characterize disease-associated regulatory elements and variants in model systems. We are beginning with a focus on autism spectrum disorder, bipolar disorder and schizophrenia, and expect that this knowledge will apply to a wide variety of psychiatric disorders. This paper outlines the motivation and design of PsychENCODE.",

author = "Schahram Akbarian and Chunyu Liu and Knowles, {James A.} and Vaccarino, {Flora M.} and Farnham, {Peggy J.} and Crawford, {Gregory E.} and Jaffe, {Andrew E.} and Dalila Pinto and Stella Dracheva and Geschwind, {Daniel H.} and Jonathan Mill and Nairn, {Angus C.} and Alexej Abyzov and Sirisha Pochareddy and Shyam Prabhakar and Sherman Weissman and Sullivan, {Patrick F.} and State, {Matthew W.} and Zhiping Weng and Peters, {Mette A.} and White, {Kevin P.} and Gerstein, {Mark B.} and Anahita Amiri and Chris Armoskus and Ashley-Koch, {Allison E.} and Taejeong Bae and Andrea Beckel-Mitchener and Berman, {Benjamin P.} and Coetzee, {Gerhard A.} and Gianfilippo Coppola and Nancy Francoeur and Menachem Fromer and Robert Gao and Kay Grennan and Jennifer Herstein and Kavanagh, {David H.} and Ivanov, {Nikolay A.} and Yan Jiang and Kitchen, {Robert R.} and Alexey Kozlenkov and Marija Kundakovic and Mingfeng Li and Zhen Li and Shuang Liu and Mangravite, {Lara M.} and Eugenio Mattei and Eirene Markenscoff-Papadimitriou and Navarro, {F{\'a}bio C.P.} and Nicole North and Larsson Omberg and David Panchision and Neelroop Parikshak and Jeremie Poschmann and Price, {Amanda J.} and Michael Purcaro and Reddy, {Timothy E.} and Panos Roussos and Shannon Schreiner and Soraya Scuderi and Robert Sebra and Mikihito Shibata and Shieh, {Annie W.} and Mario Skarica and Wenjie Sun and Vivek Swarup and Amber Thomas and Junko Tsuji and {Van Bakel}, Harm and Daifeng Wang and Yongjun Wang and Kai Wang and Werling, {Donna M.} and Willsey, {A. Jeremy} and Heather Witt and Hyejung Won and Wong, {Chloe C.Y.} and Wray, {Gregory A.} and Wu, {Emily Y.} and Xuming Xu and Lijing Yao and Geetha Senthil and Thomas Lehner and Pamela Sklar and Nenad Sestan",

note = "Publisher Copyright: {\textcopyright} 2015 Nature America, Inc.",

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doi = "10.1038/nn.4156",

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AU - Akbarian, Schahram

AU - Liu, Chunyu

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AU - Crawford, Gregory E.

AU - Jaffe, Andrew E.

AU - Pinto, Dalila

AU - Dracheva, Stella

AU - Geschwind, Daniel H.

AU - Mill, Jonathan

AU - Nairn, Angus C.

AU - Abyzov, Alexej

AU - Pochareddy, Sirisha

AU - Prabhakar, Shyam

AU - Weissman, Sherman

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AU - State, Matthew W.

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AU - Gerstein, Mark B.

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AU - Armoskus, Chris

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AU - Bae, Taejeong

AU - Beckel-Mitchener, Andrea

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AU - Kundakovic, Marija

AU - Li, Mingfeng

AU - Li, Zhen

AU - Liu, Shuang

AU - Mangravite, Lara M.

AU - Mattei, Eugenio

AU - Markenscoff-Papadimitriou, Eirene

AU - Navarro, Fábio C.P.

AU - North, Nicole

AU - Omberg, Larsson

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AU - Price, Amanda J.

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AU - Roussos, Panos

AU - Schreiner, Shannon

AU - Scuderi, Soraya

AU - Sebra, Robert

AU - Shibata, Mikihito

AU - Shieh, Annie W.

AU - Skarica, Mario

AU - Sun, Wenjie

AU - Swarup, Vivek

AU - Thomas, Amber

AU - Tsuji, Junko

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AU - Wang, Daifeng

AU - Wang, Yongjun

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AU - Werling, Donna M.

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AU - Won, Hyejung

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AU - Wu, Emily Y.

AU - Xu, Xuming

AU - Yao, Lijing

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The PsychENCODE project

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