@article{ac40be888d154b1e825bba7aa06e0981,
title = "The prognostic significance of polyclonal bone marrow plasma cells in patients with relapsing multiple myeloma",
abstract = "Prior studies have revealed that the presence of increasing number of polyclonal plasma cells (pPCs) in the bone marrow (BM) are associated with better outcomes in newly diagnosed multiple myeloma (MM) patients. This effect has not been studied in patients with MM at the time of disease relapse. We determined the prognostic value of depletion of pPCs in the BM by 7-color multiparameter flow cytometry in a series of 174 relapsing MM patients. The time to next therapy (TTNT) in those with <5% pPCs was 9.4 months versus 13.9 months in those with ≥5% pPCs (P =.0091). The median overall survival (OS) in those with <5% pPCs was 21.4 months, while the median OS was not reached in those patients with ≥5% pPCs (P =.019). Of the 109 patients with standard risk cytogenetics, the median OS of those with <5% pPCs was 28.4 months, while the median OS was not reached in those with ≥5% pPCs (P =.033). As such, <5% pPCs in the BM appears to have prognostic utility in identifying a subset of relapsing MM patients, even with standard-risk cytogenetics, who have a particularly adverse outcome.",
author = "Toshi Ghosh and Gonsalves, {Wilson I.} and Dragan Jevremovic and Angela Dispenzieri and David Dingli and Timm, {Michael M.} and Morice, {William G.} and Prashant Kapoor and Kourelis, {Taxiarchis V.} and Lacy, {Martha Q.} and Hayman, {Suzanne R.} and Buadi, {Francis K.} and Nelson Leung and Go, {Ronald S.} and Yi Lin and Russell, {Stephen J.} and Lust, {John A.} and Zeldenrust, {Steven R.} and Rahma Warsame and Hwa, {Yi L.} and Kyle, {Robert A.} and Gertz, {Morie A.} and {Vincent Rajkumar}, S. and Kumar, {Shaji K.}",
note = "Funding Information: The Mayo Clinic Hematological Malignancies Program and in part by grants CA218742, CA107476, CA168762 and CA186781 from the National Cancer Institute, Rockville, MD, USA. It is also supported in part by the Jabbs Foundation, Birmingham, United Kingdom, the Henry J. Predolin Foundation, USA and the Marion Schwartz Foundation for Multiple Myeloma. T.G., S.K.K., W.I.G., D.J., M.M.T, S.V.R., M.A.G., A.D., M.Q.L., W.G.M., M.M.T., F.K.B., D.D., N.L., R.A.K., S.R.H., R.S.G., S.J.R., S.R.Z., J.A.L., R.W., T.V.K., Y.L.H. and P.K.: These authors declare no competing financial interests. T.G., S.K.K. and W.I.G. designed the study, collected the data, analyzed the data and wrote the manuscript; D.J., M.M.T, S.V.R., M.A.G., A.D., M.Q.L., W.G.M., M.M.T., F.K.B., D.D., N.L., R.A.K., S.R.H., R.S.G., S.J.R., S.R.Z., J.A.L., R.W., T.V.K., Y.L.H. and P.K. contributed to writing and reviewing the manuscript. Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",
year = "2017",
month = sep,
doi = "10.1002/ajh.24807",
language = "English (US)",
volume = "92",
pages = "E507--E512",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "Wiley-Liss Inc.",
number = "9",
}