The posterior location of the dilator muscle induces anterior Iris bowing during dilation, even in the absence of pupillary block

Rouzbeh Amini, Julie E. Whitcomb, Muhammad K. Al-Qaisi, Taner Akkin, Sara Jouzdani, Syril Dorairaj, Tiago Prata, Elena Illitchev, Jeffrey M. Liebmann, Robert Ritch, Victor H. Barocas

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

PURPOSE. To examine the effect of the posterior location of the dilator on iris anterior curvature during dilation. METHODS. An in vivo human study, an ex vivo porcine experiment, and an in silico computational model were performed in parallel. Iris anterior curvature was measured in vivo before and after dilation by time-domain slit lamp optical coherence tomography (SL-OCT). All patients (n = 7) had undergone laser peripheral iridotomy to eliminate any pupillary block due to primary angle-closure glaucoma. In the ex vivo experiments, isolated porcine irides (n = 30) were secured at the periphery and immersed in an oxygenated Krebs-Ringer buffer. Dilation was induced pharmaceutically by the addition of 2.5% phenylephrine and 1% tropicamide. An in-house optical coherence tomography (OCT) system was used to obtain iris images before and after dilation. A finite element model was also developed based on typical geometry of the iris from the initial OCT image. The iris was modeled as a neo-Hookean solid, and the active muscle component was applied only to the region specified as the dilator. RESULTS. An increase in curvature and a decrease in chord length after dilation were observed in both experiments. In both the in vivo and ex vivo experiments, the curvature-tochord length ratio increased significantly during dilation. Computer simulations agreed well with the experimental results only when the proper anatomic position of dilator was used. CONCLUSIONS. The posterior location of the dilator contributes to the anterior iris bowing via a nonpupillary block dependent mechanism.

Original languageEnglish (US)
Pages (from-to)1188-1194
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume53
Issue number3
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Fingerprint

Iris
Dilatation
Muscles
Optical Coherence Tomography
Computer Simulation
Swine
Tropicamide
Angle Closure Glaucoma
Phenylephrine
Buffers
Lasers

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

The posterior location of the dilator muscle induces anterior Iris bowing during dilation, even in the absence of pupillary block. / Amini, Rouzbeh; Whitcomb, Julie E.; Al-Qaisi, Muhammad K.; Akkin, Taner; Jouzdani, Sara; Dorairaj, Syril; Prata, Tiago; Illitchev, Elena; Liebmann, Jeffrey M.; Ritch, Robert; Barocas, Victor H.

In: Investigative Ophthalmology and Visual Science, Vol. 53, No. 3, 01.03.2012, p. 1188-1194.

Research output: Contribution to journalArticle

Amini, R, Whitcomb, JE, Al-Qaisi, MK, Akkin, T, Jouzdani, S, Dorairaj, S, Prata, T, Illitchev, E, Liebmann, JM, Ritch, R & Barocas, VH 2012, 'The posterior location of the dilator muscle induces anterior Iris bowing during dilation, even in the absence of pupillary block', Investigative Ophthalmology and Visual Science, vol. 53, no. 3, pp. 1188-1194. https://doi.org/10.1167/iovs.11-8408
Amini, Rouzbeh ; Whitcomb, Julie E. ; Al-Qaisi, Muhammad K. ; Akkin, Taner ; Jouzdani, Sara ; Dorairaj, Syril ; Prata, Tiago ; Illitchev, Elena ; Liebmann, Jeffrey M. ; Ritch, Robert ; Barocas, Victor H. / The posterior location of the dilator muscle induces anterior Iris bowing during dilation, even in the absence of pupillary block. In: Investigative Ophthalmology and Visual Science. 2012 ; Vol. 53, No. 3. pp. 1188-1194.
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AU - Amini, Rouzbeh

AU - Whitcomb, Julie E.

AU - Al-Qaisi, Muhammad K.

AU - Akkin, Taner

AU - Jouzdani, Sara

AU - Dorairaj, Syril

AU - Prata, Tiago

AU - Illitchev, Elena

AU - Liebmann, Jeffrey M.

AU - Ritch, Robert

AU - Barocas, Victor H.

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N2 - PURPOSE. To examine the effect of the posterior location of the dilator on iris anterior curvature during dilation. METHODS. An in vivo human study, an ex vivo porcine experiment, and an in silico computational model were performed in parallel. Iris anterior curvature was measured in vivo before and after dilation by time-domain slit lamp optical coherence tomography (SL-OCT). All patients (n = 7) had undergone laser peripheral iridotomy to eliminate any pupillary block due to primary angle-closure glaucoma. In the ex vivo experiments, isolated porcine irides (n = 30) were secured at the periphery and immersed in an oxygenated Krebs-Ringer buffer. Dilation was induced pharmaceutically by the addition of 2.5% phenylephrine and 1% tropicamide. An in-house optical coherence tomography (OCT) system was used to obtain iris images before and after dilation. A finite element model was also developed based on typical geometry of the iris from the initial OCT image. The iris was modeled as a neo-Hookean solid, and the active muscle component was applied only to the region specified as the dilator. RESULTS. An increase in curvature and a decrease in chord length after dilation were observed in both experiments. In both the in vivo and ex vivo experiments, the curvature-tochord length ratio increased significantly during dilation. Computer simulations agreed well with the experimental results only when the proper anatomic position of dilator was used. CONCLUSIONS. The posterior location of the dilator contributes to the anterior iris bowing via a nonpupillary block dependent mechanism.

AB - PURPOSE. To examine the effect of the posterior location of the dilator on iris anterior curvature during dilation. METHODS. An in vivo human study, an ex vivo porcine experiment, and an in silico computational model were performed in parallel. Iris anterior curvature was measured in vivo before and after dilation by time-domain slit lamp optical coherence tomography (SL-OCT). All patients (n = 7) had undergone laser peripheral iridotomy to eliminate any pupillary block due to primary angle-closure glaucoma. In the ex vivo experiments, isolated porcine irides (n = 30) were secured at the periphery and immersed in an oxygenated Krebs-Ringer buffer. Dilation was induced pharmaceutically by the addition of 2.5% phenylephrine and 1% tropicamide. An in-house optical coherence tomography (OCT) system was used to obtain iris images before and after dilation. A finite element model was also developed based on typical geometry of the iris from the initial OCT image. The iris was modeled as a neo-Hookean solid, and the active muscle component was applied only to the region specified as the dilator. RESULTS. An increase in curvature and a decrease in chord length after dilation were observed in both experiments. In both the in vivo and ex vivo experiments, the curvature-tochord length ratio increased significantly during dilation. Computer simulations agreed well with the experimental results only when the proper anatomic position of dilator was used. CONCLUSIONS. The posterior location of the dilator contributes to the anterior iris bowing via a nonpupillary block dependent mechanism.

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