The pathology of primary progressive multiple sclerosis

Claudia F Lucchinetti, Wolfgang Bruck

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The pathological hallmark of chronic multiple sclerosis includes focal demyelination, gliosis, inflammation and axonal injury. There is limited information on whether these pathological features differ across the clinical phenotypes of the disease (relapsing-remitting, secondary progressive, and primary progressive). This review will focus on the pathological aspects of PPMS and pathogenic implications. A better understanding of the differences in PPMS pathology and pathogenesis will lead to more effective treatment strategies.

Original languageEnglish (US)
JournalMultiple Sclerosis
Volume10
Issue numberSUPPL. 1
StatePublished - Jun 2004

Fingerprint

Chronic Progressive Multiple Sclerosis
Gliosis
Demyelinating Diseases
Multiple Sclerosis
Pathology
Inflammation
Phenotype
Wounds and Injuries

Keywords

  • Axons
  • Multiple sclerosis
  • Myelin
  • Oligodendrocytes
  • Pathology

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

The pathology of primary progressive multiple sclerosis. / Lucchinetti, Claudia F; Bruck, Wolfgang.

In: Multiple Sclerosis, Vol. 10, No. SUPPL. 1, 06.2004.

Research output: Contribution to journalArticle

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