TY - JOUR
T1 - The pathology and pathobiology of bicuspid aortic valve
T2 - State of the art and novel research perspectives
AU - Mathieu, Patrick
AU - Bossé, Yohan
AU - Huggins, Gordon S.
AU - Corte, Alessandro Della
AU - Pibarot, Philippe
AU - Michelena, Hector I.
AU - Limongelli, Giuseppe
AU - Boulanger, Marie Chloé
AU - Evangelista, Arturo
AU - Bédard, Elisabeth
AU - Citro, Rodolfo
AU - Body, Simon C.
AU - Nemer, Mona
AU - Schoen, Frederick J.
N1 - Publisher Copyright:
© 2015 John Wiley and Sons Ltd and The Pathological Society of Great Britain and Ireland
PY - 2016
Y1 - 2016
N2 - Bicuspid aortic valve is the most prevalent cardiac valvular malformation. It is associated with a high rate of long-term morbidity including development of calcific aortic valve disease, aortic regurgitation and concomitant thoracic aortic aneurysm and dissection. Recently, basic and translational studies have identified some key processes involved in the development of bicuspid aortic valve and its morbidity. The development of aortic valve disease and thoracic aortic aneurysm and dissection is the result of complex interactions between genotypes, environmental risk factors and specific haemodynamic conditions created by bicuspid aortic valve anatomy. Herein, we review the pathobiology of bicuspid aortic valve with a special emphasis on translational aspects of these basic findings. Important but unresolved problems in the pathology of bicuspid aortic valve and thoracic aortic aneurysm and dissection are discussed, along with the molecular processes involved.
AB - Bicuspid aortic valve is the most prevalent cardiac valvular malformation. It is associated with a high rate of long-term morbidity including development of calcific aortic valve disease, aortic regurgitation and concomitant thoracic aortic aneurysm and dissection. Recently, basic and translational studies have identified some key processes involved in the development of bicuspid aortic valve and its morbidity. The development of aortic valve disease and thoracic aortic aneurysm and dissection is the result of complex interactions between genotypes, environmental risk factors and specific haemodynamic conditions created by bicuspid aortic valve anatomy. Herein, we review the pathobiology of bicuspid aortic valve with a special emphasis on translational aspects of these basic findings. Important but unresolved problems in the pathology of bicuspid aortic valve and thoracic aortic aneurysm and dissection are discussed, along with the molecular processes involved.
KW - aorta dilation
KW - bicuspid aortic valve
KW - calcific aortic valve disease
KW - pathophysiology
KW - thoracic aortic aneurysm
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U2 - 10.1002/cjp2.21
DO - 10.1002/cjp2.21
M3 - Article
AN - SCOPUS:85056746531
SN - 2056-4538
VL - 2
SP - 195
EP - 206
JO - Journal of Pathology: Clinical Research
JF - Journal of Pathology: Clinical Research
IS - 1
ER -