Abstract
Cardiac cell therapy has emerged as a controversial yet promising therapeutic strategy. Both experimental data and clinical applications in this field have shown modest but tangible benefits on cardiac structure and function and underscore that transplanted stem-progenitor cells can attenuate the postinfarct microenvironment. The paracrine factors secreted by these cells represent a pivotal mechanism underlying the benefits of cell-mediated cardiac repair. This article reviews key studies behind the paracrine effect related to the cardiac reparative effects of cardiac cell therapy.
Original language | English (US) |
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Pages (from-to) | 652-662 |
Number of pages | 11 |
Journal | Journal of cardiovascular translational research |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2010 |
Keywords
- Cardiac repair
- Paracrine effect
- Stem-Progenitor cells
- Therapy
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Pharmaceutical Science
- Cardiology and Cardiovascular Medicine
- Genetics(clinical)