The paracrine effect: Pivotal mechanism in cell-based cardiac repair

Simon Maltais, Jacques P. Tremblay, Louis P. Perrault, Hung Q. Ly

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Cardiac cell therapy has emerged as a controversial yet promising therapeutic strategy. Both experimental data and clinical applications in this field have shown modest but tangible benefits on cardiac structure and function and underscore that transplanted stem-progenitor cells can attenuate the postinfarct microenvironment. The paracrine factors secreted by these cells represent a pivotal mechanism underlying the benefits of cell-mediated cardiac repair. This article reviews key studies behind the paracrine effect related to the cardiac reparative effects of cardiac cell therapy.

Original languageEnglish (US)
Pages (from-to)652-662
Number of pages11
JournalJournal of Cardiovascular Translational Research
Volume3
Issue number6
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

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Cell- and Tissue-Based Therapy
Stem Cells
Therapeutics

Keywords

  • Cardiac repair
  • Paracrine effect
  • Stem-Progenitor cells
  • Therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

Cite this

The paracrine effect : Pivotal mechanism in cell-based cardiac repair. / Maltais, Simon; Tremblay, Jacques P.; Perrault, Louis P.; Ly, Hung Q.

In: Journal of Cardiovascular Translational Research, Vol. 3, No. 6, 01.01.2010, p. 652-662.

Research output: Contribution to journalReview article

Maltais, Simon ; Tremblay, Jacques P. ; Perrault, Louis P. ; Ly, Hung Q. / The paracrine effect : Pivotal mechanism in cell-based cardiac repair. In: Journal of Cardiovascular Translational Research. 2010 ; Vol. 3, No. 6. pp. 652-662.
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