TY - JOUR
T1 - The natural history of multiple sclerosis
T2 - A geographically based study: 2 PREDICTIVE value OF the EARLY clinical course
AU - Weinshenker, B. G.
AU - Bass, B.
AU - Rice, G. P.A.
AU - Noseworthy, J.
AU - Carriere, W.
AU - Baskerville, J.
AU - Ebers, G. C.
N1 - Funding Information:
This work has been supported by a grant from the MS Society of Canada. Dr Brian G. Weinshenker is a fellow of the MS Society of Canada. Dr George Ebers and Dr George Rice are career investigators of the Ontario Ministry of Health. Dr John Noseworthy is a career investigator of the MS Society of Canada. Carole Sutherland and Vivian Gordon-Weinshenker provided expert technical assistance with preparation of the manuscript.
PY - 1989/12
Y1 - 1989/12
N2 - Controversy exists regarding the predictive value of the early clinical courser of multiple sclerosis (MS). Three parameters often considered are the attack rate, the first interattack interval and the rate at which disability develops in teh early years of the disease. We have recorded the time to reach successive levels of disability defined by the Kurtzke Disability Status Scale (DSS) in 1,099 MS patients followed at University Hospital, London, Canada between 1972 and 1984. Our population is particularly suitable because of its size, the high degree of ascertainment of cases in the community, and the regular follow-up provided. Life table analysis was used to compare survival in patients stratified according to the above three parameters using DSS 6 as end point. Significant differences were evident in the survival distributions. Despite the extensive interindividual variation in the rate at which disability developed, the early course of MS may be useful in determining the relative risk of rapid progression.
AB - Controversy exists regarding the predictive value of the early clinical courser of multiple sclerosis (MS). Three parameters often considered are the attack rate, the first interattack interval and the rate at which disability develops in teh early years of the disease. We have recorded the time to reach successive levels of disability defined by the Kurtzke Disability Status Scale (DSS) in 1,099 MS patients followed at University Hospital, London, Canada between 1972 and 1984. Our population is particularly suitable because of its size, the high degree of ascertainment of cases in the community, and the regular follow-up provided. Life table analysis was used to compare survival in patients stratified according to the above three parameters using DSS 6 as end point. Significant differences were evident in the survival distributions. Despite the extensive interindividual variation in the rate at which disability developed, the early course of MS may be useful in determining the relative risk of rapid progression.
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U2 - 10.1093/brain/112.6.1419
DO - 10.1093/brain/112.6.1419
M3 - Article
C2 - 2597989
AN - SCOPUS:0024796845
SN - 0006-8950
VL - 112
SP - 1419
EP - 1428
JO - Brain
JF - Brain
IS - 6
ER -