The nano-plasma interface

Implications of the protein corona

Joy Wolfram, Yong Yang, Jianliang Shen, Asad Moten, Chunying Chen, Haifa Shen, Mauro Ferrari, Yuliang Zhao

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume124
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Fingerprint

Nanoparticles
coronas
proteins
Proteins
Plasmas
nanoparticles
Nanomedicine
Medical nanotechnology
blood plasma
Molecular recognition
Beam plasma interactions
Biomolecules
biocompatibility
Macromolecules
Biocompatibility
macromolecules
toxicity
Toxicity
drugs
Blood

Keywords

  • Nano-bio interface
  • Nanoparticles
  • Plasma
  • Protein corona
  • Proteins

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

The nano-plasma interface : Implications of the protein corona. / Wolfram, Joy; Yang, Yong; Shen, Jianliang; Moten, Asad; Chen, Chunying; Shen, Haifa; Ferrari, Mauro; Zhao, Yuliang.

In: Colloids and Surfaces B: Biointerfaces, Vol. 124, 01.12.2014, p. 17-24.

Research output: Contribution to journalArticle

Wolfram, Joy ; Yang, Yong ; Shen, Jianliang ; Moten, Asad ; Chen, Chunying ; Shen, Haifa ; Ferrari, Mauro ; Zhao, Yuliang. / The nano-plasma interface : Implications of the protein corona. In: Colloids and Surfaces B: Biointerfaces. 2014 ; Vol. 124. pp. 17-24.
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