The N terminal region of human tau is present in Alzheimer's disease protein A68 and is incorporated into paired helical filaments

Alex Crowe, Hanna Ksiezak-Reding, Wan Kyng Liu, Dennis W Dickson, Shu Hui Yen

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Antibody (Ab) E-1 was raised to the amino terminus (19 to 33 amino acid residues) of human tau. It recognized Alzheimer's disease proteins A68 (MW 60, 64, 68 kd), labeled paired helical filaments, and had no reactivity with tau from rat, mouse, and bovine brains. The results indicate that the N terminus of tau is incorporated in A68 proteins and paired helical filaments and that human tau proteins contain species-specific amino acid sequences.

Original languageEnglish (US)
Pages (from-to)1463-1470
Number of pages8
JournalAmerican Journal of Pathology
Volume139
Issue number6
StatePublished - Dec 1991
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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