TY - JOUR
T1 - The N terminal region of human tau is present in Alzheimer's disease protein A68 and is incorporated into paired helical filaments
AU - Crowe, Alex
AU - Ksiezak-Reding, Hanna
AU - Liu, Wan Kyng
AU - Dickson, Dennis W.
AU - Yen, Shu Hui
PY - 1991/12
Y1 - 1991/12
N2 - Antibody (Ab) E-1 was raised to the amino terminus (19 to 33 amino acid residues) of human tau. It recognized Alzheimer's disease proteins A68 (MW 60, 64, 68 kd), labeled paired helical filaments, and had no reactivity with tau from rat, mouse, and bovine brains. The results indicate that the N terminus of tau is incorporated in A68 proteins and paired helical filaments and that human tau proteins contain species-specific amino acid sequences.
AB - Antibody (Ab) E-1 was raised to the amino terminus (19 to 33 amino acid residues) of human tau. It recognized Alzheimer's disease proteins A68 (MW 60, 64, 68 kd), labeled paired helical filaments, and had no reactivity with tau from rat, mouse, and bovine brains. The results indicate that the N terminus of tau is incorporated in A68 proteins and paired helical filaments and that human tau proteins contain species-specific amino acid sequences.
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M3 - Article
C2 - 1721492
AN - SCOPUS:0026342276
SN - 0002-9440
VL - 139
SP - 1463
EP - 1470
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 6
ER -