The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene

Roberto Diaz, Daniel Ahn, Lluis Lopez-Barcons, Marcos Malumbres, Ignacio Perez De Castro, Jeffrey Lue, Neus Ferrer-Miralles, Ramon Mangues, Jerry Tsong, Roberto Garcia, Roman Perez-Soler, Angel Pellicer

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

ras proto-oncogenes have traditionally been associated with the regulation and promotion of cell growth. We have induced thymic lymphomas in N-ras-/- mice and in transgenic mice that overexpress wild-type N-ras and found that the lack of wild-type N-ras alleles favors the development of thymic lymphomas, whereas overexpression of wild-type N-ras protects against thymic lymphomagenesis in the presence or absence of its oncogene. To investigate the inhibitory role of wild-type N-ras in in vitro transformation, we introduced wild-type N-ras in N-ras-deficient tumor cells that lack ras activating mutations and found decreased growth in both low serum and soft agar. Taken together, our results indicate that wild-type N-ras has "tumor suppressor" activity, even in the absence of its oncogenic allele.

Original languageEnglish (US)
Pages (from-to)4514-4518
Number of pages5
JournalCancer research
Volume62
Issue number15
StatePublished - Aug 1 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene'. Together they form a unique fingerprint.

  • Cite this

    Diaz, R., Ahn, D., Lopez-Barcons, L., Malumbres, M., De Castro, I. P., Lue, J., Ferrer-Miralles, N., Mangues, R., Tsong, J., Garcia, R., Perez-Soler, R., & Pellicer, A. (2002). The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer research, 62(15), 4514-4518.