The mechanical properties of tail tendon fascicles from lubricin knockout, wild type and heterozygous mice

John Reuvers, Andrew R. Thoreson, Chunfeng Zhao, Ling Zhang, Gregory D. Jay, Kai Nan An, Matthew L. Warman, Peter C. Amadio

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The purpose of this study was to analyze the effects of lubricin on tendon stiffness and viscoelasticity. A total of 36 mice were tested with 12 mice in each of the following groups: lubricin knock-out (-/-), heterozygous (+/-) and wild-type (+/+). A ramp test was used to determine the elastic modulus by pulling the fascicles to 2.5% strain amplitude at a rate of 0.05. mm/s. Then, followed by a relaxation test that pulled the fascicles to 5% strain amplitude at a rate of 2. mm/s. The fascicles were allowed to relax for 2. min at the maximum strain and a single-cycle relaxation ratio was used to characterize viscoelastic properties. There was no significant difference in the Young's modulus between the three groups (p> 0.05), but the knockout mice had a significantly (p< 0.05) lower relaxation ratio than the wild type mice. Based on these data, we concluded that lubricin expression has an effect on the viscoelastic properties of tendon fascicles. The clinical significance of this finding, if any, remains to be demonstrated.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalJournal of Structural Biology
Volume176
Issue number1
DOIs
StatePublished - Oct 1 2011

Keywords

  • Fascicle
  • Lubricin
  • Mechanical
  • Tendon
  • Viscoelasticity

ASJC Scopus subject areas

  • Structural Biology

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