The mayo clinic biobank

A building block for individualized medicine

Janet E Olson, Euijung Ryu, Kiley J. Johnson, Barbara A. Koenig, Karen J. Maschke, Jody A. Morrisette, Mark Liebow, Paul Y Takahashi, Zachary S. Fredericksen, Ruchi G. Sharma, Kari S. Anderson, Matthew A. Hathcock, Jason A. Carnahan, Jyotishman Pathak, Noralane Morey Lindor, Timothy J. Beebe, Stephen N Thibodeau, James R Cerhan

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Objective: To report the design and implementation of the first 3 years of enrollment of the Mayo Clinic Biobank. Patients and Methods: Preparations for this biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing, with a target goal of 50,000. Any Mayo Clinic patient who is 18 years or older, able to consent, and a US resident is eligible to participate. Each participant completes a health history questionnaire, provides a blood sample, and allows access to existing tissue specimens and all data from their Mayo Clinic electronic medical record. A community advisory board provides ongoing advice and guidance on complex decisions. Results: After 3 years of recruitment, 21,736 individuals have enrolled. Fifty-eight percent (12,498) of participants are female and 95% (20,541) of European ancestry. Median participant age is 62 years. Seventyfour percent (16,171) live in Minnesota, with 42% (9157) from Olmsted County, where the Mayo Clinic in Rochester, Minnesota, is located. The 5 most commonly self-reported conditions are hyperlipidemia (8979, 41%), hypertension (8174, 38%), osteoarthritis (6448, 30%), any cancer (6224, 29%), and gastroesophageal reflux disease (5669, 26%). Among patients with self-reported cancer, the 5 most common types are nonmelanoma skin cancer (2950, 14%), prostate cancer (1107, 12% in men), breast cancer (941, 4%), melanoma (692, 3%), and cervical cancer (240, 2% in women). Fifty-six percent (12,115) of participants have at least 15 years of electronic medical record history. To date, more than 60 projects and more than 69,000 samples have been approved for use. Conclusion: The Mayo Clinic Biobank has quickly been established as a valuable resource for researchers.

Original languageEnglish (US)
Pages (from-to)952-962
Number of pages11
JournalMayo Clinic Proceedings
Volume88
Issue number9
DOIs
StatePublished - 2013

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Precision Medicine
Electronic Health Records
Skin Neoplasms
Gastroesophageal Reflux
Hyperlipidemias
Uterine Cervical Neoplasms
Osteoarthritis
Melanoma
Neoplasms
Prostatic Neoplasms
History
Research Personnel
Breast Neoplasms
Hypertension
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The mayo clinic biobank : A building block for individualized medicine. / Olson, Janet E; Ryu, Euijung; Johnson, Kiley J.; Koenig, Barbara A.; Maschke, Karen J.; Morrisette, Jody A.; Liebow, Mark; Takahashi, Paul Y; Fredericksen, Zachary S.; Sharma, Ruchi G.; Anderson, Kari S.; Hathcock, Matthew A.; Carnahan, Jason A.; Pathak, Jyotishman; Lindor, Noralane Morey; Beebe, Timothy J.; Thibodeau, Stephen N; Cerhan, James R.

In: Mayo Clinic Proceedings, Vol. 88, No. 9, 2013, p. 952-962.

Research output: Contribution to journalArticle

Olson, JE, Ryu, E, Johnson, KJ, Koenig, BA, Maschke, KJ, Morrisette, JA, Liebow, M, Takahashi, PY, Fredericksen, ZS, Sharma, RG, Anderson, KS, Hathcock, MA, Carnahan, JA, Pathak, J, Lindor, NM, Beebe, TJ, Thibodeau, SN & Cerhan, JR 2013, 'The mayo clinic biobank: A building block for individualized medicine', Mayo Clinic Proceedings, vol. 88, no. 9, pp. 952-962. https://doi.org/10.1016/j.mayocp.2013.06.006
Olson, Janet E ; Ryu, Euijung ; Johnson, Kiley J. ; Koenig, Barbara A. ; Maschke, Karen J. ; Morrisette, Jody A. ; Liebow, Mark ; Takahashi, Paul Y ; Fredericksen, Zachary S. ; Sharma, Ruchi G. ; Anderson, Kari S. ; Hathcock, Matthew A. ; Carnahan, Jason A. ; Pathak, Jyotishman ; Lindor, Noralane Morey ; Beebe, Timothy J. ; Thibodeau, Stephen N ; Cerhan, James R. / The mayo clinic biobank : A building block for individualized medicine. In: Mayo Clinic Proceedings. 2013 ; Vol. 88, No. 9. pp. 952-962.
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