The management of mucous membrane pemphigoid and pemphigus

Richelle M. Knudson, Amer N. Kalaaji, Alison Bruce

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Mucous membrane pemphigoid and pemphigus vulgaris are autoimmune blistering disorders in which many similar drugs and therapeutic strategies are utilized. In general, localized disease can be treated with topical agents. In contrast, patients with more severe and progressive disease usually require a combination of systemic corticosteroids and immunosuppressive medications. Oral corticosteroids, adjuvant immunosuppressive agents, antibiotics such as dapsone and immunomodulatory procedures like intravenous immunoglobulin are the main therapeutic agents used in treating these two disorders. Much of the morbidity and mortality associated with these disorders are related to the sites involved and to the drugs used for therapy. Treatment should be individualized based on severity, extent, and rate of progression of disease, comorbidities, and age of the patient. Serum levels of specific autoantibodies and indirect immunofluorescence titers, in certain cases, can be used to monitor response to therapy.

Original languageEnglish (US)
Pages (from-to)268-280
Number of pages13
JournalDermatologic Therapy
Volume23
Issue number3
DOIs
StatePublished - 2010

Fingerprint

Bullous Pemphigoid
Pemphigus
Mucous Membrane
Immunosuppressive Agents
Adrenal Cortex Hormones
Dapsone
Intravenous Immunoglobulins
Therapeutics
Indirect Fluorescent Antibody Technique
Autoantibodies
Disease Progression
Comorbidity
Anti-Bacterial Agents
Morbidity
Drug Therapy
Mortality
Serum
Pharmaceutical Preparations

Keywords

  • Cicatricial pemphigoid
  • Mucous membrane pemphigoid
  • Pemphigus vulgaris
  • Therapy

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

The management of mucous membrane pemphigoid and pemphigus. / Knudson, Richelle M.; Kalaaji, Amer N.; Bruce, Alison.

In: Dermatologic Therapy, Vol. 23, No. 3, 2010, p. 268-280.

Research output: Contribution to journalArticle

Knudson, Richelle M. ; Kalaaji, Amer N. ; Bruce, Alison. / The management of mucous membrane pemphigoid and pemphigus. In: Dermatologic Therapy. 2010 ; Vol. 23, No. 3. pp. 268-280.
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