The kinetics of anterior chamber ofloxacin penetration

Charles S. Bouchard, Kevin K. King, Jonathan M Holmes

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Thirty-five patients received topical ofloxacin 0.3% before routine cataract surgery. Ofloxacin was administered one drop every 2 h for five doses 1 day before surgery and one drop every 5 min for five doses immediately before surgery. Aqueous sampling was performed at variable periods 30-150 min after the last topical dose. The mean aqueous ofloxacin concentration was 793 ± 516 ng/ml (range, 143-2,400 ng/ml. A significant correlation between time from last dose and aqueous humor concentration was found (r = 0.39, p = 0.025). The mean ofloxacin concentration was greater in those patients who received their last dose >1 h before aqueous aspiration (957 ± 559 ng/ml versus 554 ± 338 ng/ml, p = 0.02). From a best-fit scatter plot of concentration versus time, the maximal aqueous concentration of 1.000 ng/ml occurs at ~2 h after topical administration.

Original languageEnglish (US)
Pages (from-to)72-75
Number of pages4
JournalCornea
Volume15
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Ofloxacin
Anterior Chamber
Topical Administration
Aqueous Humor
Ambulatory Surgical Procedures
Cataract

Keywords

  • Aqueous
  • Cataract surgery
  • Fluoroquinolone
  • Ofloxacin
  • Pharmacokinetics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Bouchard, C. S., King, K. K., & Holmes, J. M. (1996). The kinetics of anterior chamber ofloxacin penetration. Cornea, 15(1), 72-75.

The kinetics of anterior chamber ofloxacin penetration. / Bouchard, Charles S.; King, Kevin K.; Holmes, Jonathan M.

In: Cornea, Vol. 15, No. 1, 1996, p. 72-75.

Research output: Contribution to journalArticle

Bouchard, CS, King, KK & Holmes, JM 1996, 'The kinetics of anterior chamber ofloxacin penetration', Cornea, vol. 15, no. 1, pp. 72-75.
Bouchard, Charles S. ; King, Kevin K. ; Holmes, Jonathan M. / The kinetics of anterior chamber ofloxacin penetration. In: Cornea. 1996 ; Vol. 15, No. 1. pp. 72-75.
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