The kinetics of anterior chamber ofloxacin penetration

Charles S. Bouchard, Kevin K. King, Jonathan M. Holmes

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Thirty-five patients received topical ofloxacin 0.3% before routine cataract surgery. Ofloxacin was administered one drop every 2 h for five doses 1 day before surgery and one drop every 5 min for five doses immediately before surgery. Aqueous sampling was performed at variable periods 30-150 min after the last topical dose. The mean aqueous ofloxacin concentration was 793 ± 516 ng/ml (range, 143-2,400 ng/ml. A significant correlation between time from last dose and aqueous humor concentration was found (r = 0.39, p = 0.025). The mean ofloxacin concentration was greater in those patients who received their last dose >1 h before aqueous aspiration (957 ± 559 ng/ml versus 554 ± 338 ng/ml, p = 0.02). From a best-fit scatter plot of concentration versus time, the maximal aqueous concentration of 1.000 ng/ml occurs at ~2 h after topical administration.

Original languageEnglish (US)
Pages (from-to)72-75
Number of pages4
JournalCornea
Volume15
Issue number1
DOIs
StatePublished - Jan 1 1996

Keywords

  • Aqueous
  • Cataract surgery
  • Fluoroquinolone
  • Ofloxacin
  • Pharmacokinetics

ASJC Scopus subject areas

  • Ophthalmology

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