TY - JOUR
T1 - The Kindlin protein family
T2 - new members to the club of focal adhesion proteins
AU - Meves, Alexander
AU - Stremmel, Christopher
AU - Gottschalk, Kay
AU - Fässler, Reinhard
N1 - Funding Information:
We thank Roy Zent for careful reading of the manuscript. A.M. is a Mayo Clinic Scholar and supported by the Mayo Clinic/Mayo Foundation. The work of the Fässler lab is funded by the Deutsche Forschungsgemeinschaft (DFG), Bundesministerium für Bildung und Forschung (BMBF) and the Max Planck Society.
PY - 2009/10
Y1 - 2009/10
N2 - Kindlins are a group of proteins that have recently attracted attention for their ability to bind and activate integrins. Moreover, they have also been linked to inherited and acquired human diseases including Kindler syndrome, leukocyte adhesion deficiency, and cancer. Although most studies have focused on kindlins as key regulatory components of cell-extracellular matrix junctions such as focal adhesions, preliminary data suggest the involvement of additional cellular compartments in mediating their functions, particularly at cell-cell contacts and the nucleus. Investigating the many roles of kindlins is likely to expand and sharpen our view on the versatility of integrin-mediated cell adhesion, the nuclear function of focal adhesion proteins, and the crosstalk between cell-cell and cell-matrix adhesions in health and disease.
AB - Kindlins are a group of proteins that have recently attracted attention for their ability to bind and activate integrins. Moreover, they have also been linked to inherited and acquired human diseases including Kindler syndrome, leukocyte adhesion deficiency, and cancer. Although most studies have focused on kindlins as key regulatory components of cell-extracellular matrix junctions such as focal adhesions, preliminary data suggest the involvement of additional cellular compartments in mediating their functions, particularly at cell-cell contacts and the nucleus. Investigating the many roles of kindlins is likely to expand and sharpen our view on the versatility of integrin-mediated cell adhesion, the nuclear function of focal adhesion proteins, and the crosstalk between cell-cell and cell-matrix adhesions in health and disease.
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U2 - 10.1016/j.tcb.2009.07.006
DO - 10.1016/j.tcb.2009.07.006
M3 - Review article
C2 - 19766491
AN - SCOPUS:70349312643
SN - 0962-8924
VL - 19
SP - 504
EP - 513
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 10
ER -